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Review
. 2024 Oct 30;25(21):11648.
doi: 10.3390/ijms252111648.

Neurotensin and Its Involvement in Female Hormone-Sensitive Cancers

Ninon Bertrand  1 , Romane Mougel  2 , George Riley  3 , Marie Bruand  4 , Guillaume Gauchotte  5   6 , Mikaël Agopiantz  2   6
Affiliations
Review

Neurotensin and Its Involvement in Female Hormone-Sensitive Cancers

Ninon Bertrand et al. Int J Mol Sci. .

Abstract

Neurotensin (NT) is a peptide involved in digestion, neuromodulation, and cancer progression. NT and its receptors (NTR1 and SORT1 mainly) have been widely studied in oncology. Data show that NT expression is under the control of sex steroid hormones, in particular estradiol. We focused on its involvement in three main female hormone-sensitive cancers, breast, ovarian, and endometrial cancer, in a narrative review. NT, NTR1, and SORT1 are mostly expressed in these three cancers, and their involvement in oncologic processes such as proliferation and invasion seems to match, as does their impact on prognosis for most. The development of NT receptor-targeted therapies, including theranostics and radioligand treatments, presents a promising avenue for personalized cancer treatment.

Keywords: breast cancer; endometrial cancer; neurotensin; ovarian cancer.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Synthesis of roles and perspectives for NT and its receptors in breast, ovarian, and endometrial cancers. NT: neurotensin; NTR1: neurotensin receptor 1; NTR2: neurotensin receptor 2; SORT1: sortilin.
See this image and copyright information in PMC

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