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Review
. 2024 Oct 31;25(21):11713.
doi: 10.3390/ijms252111713.

Potential Anticancer Effects of Isoflavone Prunetin and Prunetin Glycoside on Apoptosis Mechanisms

Se Hyo Jeong  1 , Hun Hwan Kim  1 , Min Yeong Park  1 , Pritam Bhangwan Bhosale  1 , Abuyaseer Abusaliya  1 , Kwang Hyun Hwang  2 , Yeon Gyu Moon  2 , Jeong Doo Heo  3 , Je Kyung Seong  4 , Meejung Ahn  5 , Kwang Il Park  1 , Chung Kil Won  1 , Gon Sup Kim  1
Affiliations
Review

Potential Anticancer Effects of Isoflavone Prunetin and Prunetin Glycoside on Apoptosis Mechanisms

Se Hyo Jeong et al. Int J Mol Sci. .

Abstract

Cancer is a deadly disease caused by cells that deviate from the normal differentiation and proliferation behaviors and continue to multiply. There is still no definitive cure, and many side effects occur even after treatment. However, apoptosis, one of the programs imprinted on cells, is becoming an important concept in controlling cancer. Flavonoids are polyphenolic compounds found in plants, are naturally bioactive compounds, have been studied for their anticancer effects, and have fewer side effects than chemical treatments. Isoflavones are phytoestrogens belonging to the flavonoid family, and this review discusses in depth the potential anticancer effects of prunetin, one of the many flavonoid families, via the apoptotic mechanism. In addition, a glycoside called prunetin glucoside has been investigated for its anticancer effects through apoptotic mechanisms. The primary intention of this review is to identify the effects of prunetin and its glycoside, prunetin glucoside, on cell death signaling pathways in various cancers to enhance the potential anticancer effects of these natural compounds.

Keywords: anticancer; apoptosis; isoflavone; prunetin glucosides; signaling pathway.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Intrinsic and extrinsic pathways of apoptosis.
Figure 2
Figure 2
Basic structures of flavonoids and their sub-classes.
Figure 3
Figure 3
Glycoside and aglycone forms of various isoflavones.
Figure 4
Figure 4
Prunetin and prunetin glycoside structures.
Figure 5
Figure 5
Apoptosis mechanisms of prunetin and prunetin glycosides.
See this image and copyright information in PMC

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