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. 2024 Oct 22;16(21):3579.
doi: 10.3390/nu16213579.

Link Between Metabolic Syndrome, Blood Lipid Markers, Dietary Lipids, and Survival in Women with Early-Stage Breast Cancer

Christine Bobin-Dubigeon  1   2   3 , Loic Campion  2 , Clémence Bossard  1   3 , Elsa Rossignol  2 , Jean-Sébastien Frenel  2 , Mario Campone  2 , Jean-Marie Bard  3
Affiliations

Link Between Metabolic Syndrome, Blood Lipid Markers, Dietary Lipids, and Survival in Women with Early-Stage Breast Cancer

Christine Bobin-Dubigeon et al. Nutrients. .

Abstract

Background/objectives: Nearly 10% of cancers could be prevented through dietary changes. In addition, breast cancer (BC) is the most common cancer in women worldwide. Inadequate diet may lead to several metabolic abnormalities, including metabolic syndrome (MS). The goal of our study is to evaluate the link between survival after BC and MS, as well as diet lipids and circulating lipids.

Methods: This study was performed in an early-stage BC cohort (n = 73): MS, dietary lipids, and circulating biological parameters, including leucocyte expression in cholesterol carriers (ATP-binding cassette transporter ABCA1, ABCG1), were determined before any medication intervention. The data of each patient were analyzed using univariate logistic regression and are expressed by HR, 95%CI [5th-95th]. All these parameters were explored with survival parameters using Cox regression analyses.

Results: Overall survival (OS) and invasive disease-free survival (iDFS) were significantly longer for the women without metabolic syndrome with HR 4.7 [1.11-19.92] and p = 0.036, and 3.58 [1.23-10.44] and p = 0.019, respectively. The expression of ABCG1 in peripheral leucocytes, an ATP-binding cassette transporter involved in cholesterol and phospholipid trafficking, is significantly associated with iDFS (1.38 [1.1-1.9], p = 0.0048). MS is associated with more pejorative survival parameters in early-stage breast cancer. Paraoxonase (or PON) activities differ according to PON gene polymorphism, but also diet. A link between PON activities and survival parameters was suggested and needs to be clarified.

Conclusions: This study emphasizes the link between survival parameters of early-stage breast cancer, metabolic syndrome, and some parameters related to lipid metabolism.

Keywords: breast cancer; dietary habits; lipids; metabolic syndrome; nutrition; paraoxonase.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of this study.
Figure 2
Figure 2
Overall survival with and without the presence of metabolic syndrome (MS+ vs. MS−); n = 68.
Figure 3
Figure 3
iDFS with and without the presence of metabolic syndrome (MS+ vs. MS−); n = 68.
Figure 4
Figure 4
Relationship between ABCG1 leucocyte expression and the ratio of dietary ω6/ω3 (A) and omega 3, expressed as % of total dietary lipids (B).
See this image and copyright information in PMC

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