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. 2024 Oct 23;16(21):3591.
doi: 10.3390/nu16213591.

A Systematic Review of the Effect of Polyphenols on Alterations of the Intestinal Microbiota and Shared Bacterial Profiles Between Metabolic Syndrome and Acne

Sara Ilari  1 , Saverio Nucera  2 , Lucrezia Morabito  2 , Rosamaria Caminiti  2 , Valeria Mazza  2 , Giovanna Ritorto  2 , Sara Ussia  2 , Lucia Carmela Passacatini  1 , Roberta Macrì  2 , Federica Scarano  2 , Maria Serra  2 , Elisabetta Scali  2 , Jessica Maiuolo  2 , Francesca Oppedisano  2 , Ernesto Palma  2 , Saverio Muscoli  3 , Stefania Proietti  4 , Carlo Tomino  1 , Vincenzo Mollace  2 , Carolina Muscoli  2
Affiliations

A Systematic Review of the Effect of Polyphenols on Alterations of the Intestinal Microbiota and Shared Bacterial Profiles Between Metabolic Syndrome and Acne

Sara Ilari et al. Nutrients. .

Abstract

Introduction: Microbiota, composed of micro-organisms like bacteria, viruses, and non-pathogenic fungi, plays a crucial role in digestion, vitamin production, and protection against dangerous microbes. Several factors, including age, diet, alcohol consumption, stress, environmental microorganisms, and therapies (particularly antibiotics), as well as birth and nursing, could modify the microbiota. Recent research has highlighted its alteration and involvement in a various disease, including metabolic syndrome and acne. This systematic review aimed to identify common biomarkers and microbiota alterations shared between metabolic syndrome and acne, and to explore how the potential prebiotic activities of polyphenols may promote intestinal eubiosis. Materials and methods: A comprehensive search in PubMed and EMBASE resulted in 4142 articles, from which nine studies were selected based on specific criteria after removing duplicates and reviewing abstracts and full texts. All studies correlated the microbiota alteration in both pathologies and the activity of polyphenols in metabolic syndrome. Results: This review suggests that acne may be influenced by some of the same microorganisms involved in metabolic syndrome. While the literature highlights the effectiveness of polyphenols in treating metabolic syndrome, no studies have yet demonstrated their specific impact on acne. Conclusions: The research points to the potential benefits of polyphenols in modulating the microbiota, which could be relevant for individuals with metabolic syndrome. However, due to the limited data available, it was not possible to establish a direct correlation between metabolic syndrome and acne.

Keywords: bacteria; metabolism; microbiota; nutraceuticals; systematic review.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Different microbial species inhabit the host’s gut microbiota.
Figure 2
Figure 2
Oxidative stress and metabolic syndrome contribute to the development of acne vulgaris.
Figure 3
Figure 3
Properties of polyphenols.
Figure 4
Figure 4
PRISMA flowchart.
See this image and copyright information in PMC

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