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Review
. 2024 Oct 31;16(21):3740.
doi: 10.3390/nu16213740.

Effects of Bisphenol A on the Risk of Developing Obesity

Mónica García García  1 , Yolanda Picó  2   3 , María Morales-Suárez-Varela  1   3
Affiliations
Review

Effects of Bisphenol A on the Risk of Developing Obesity

Mónica García García et al. Nutrients. .

Abstract

Background: Every year the global incidence of obesity increases considerably and among the factors that favor it is bisphenol A (BPA), an endocrine disruptor widely used in plastics and omnipresent in many everyday objects.

Methods: A total of 19 studies published between 2018 and 2023 that addressed the relationship between BPA exposure and obesity were included in this review in order to better understand its behavior and mechanisms of action.

Results: The studies reviewed conclude that BPA is an obesogen that alters the function of hormonal receptors, promotes metabolic syndrome, affects certain genes, etc., leading to a greater risk of developing obesity. With important emphasis on the ability to cause epigenetic changes, thus transmitting the effects to offspring when exposure has occurred during critical stages of development such as during gestation or the perinatal period.

Conclusions: There is sufficient evidence to show that BPA is a risk factor in the development of obesity. Even so, further research is necessary to exhaustively understand the causal relationship between the two in order to develop prevention measures and avoid possible future adverse effects.

Keywords: bisphenol A; endocrine disruptor; epigenetics; metabolic syndrome; obesity; obesogenic.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Chemical structure of bisphenol A (A), bisphenol S (B), and bisphenol F (C).
Figure 2
Figure 2
Study selection flow diagram.
See this image and copyright information in PMC

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