Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2024;32(6):5047-5063.
doi: 10.3233/THC-240695.

The intervention effect of psychological care combined with ondansetron, dexamethasone, and promethazine hydrochloride on chemotherapy in breast cancer surgical patients

Xia Li  1 , Lili Dong  2
Affiliations
Randomized Controlled Trial

The intervention effect of psychological care combined with ondansetron, dexamethasone, and promethazine hydrochloride on chemotherapy in breast cancer surgical patients

Xia Li et al. Technol Health Care. 2024.

Abstract

Background: Breast cancer (BC) is one of the most common malignancies in women and imposes a significant health burden globally. According to data from the World Health Organization, the incidence of BC has been increasing steadily over the years. It has become one of the leading causes of cancer-related death among women worldwide.

Objective: This work was to evaluate the combined intervention effect of psychological care along with the use of ondansetron, dexamethasone, and promethazine hydrochloride in breast cancer (BC) patients undergoing chemotherapy, including their impact on nausea and vomiting control, quality of life (QoL), and psychological status.

Methods: 64 BC patients undergoing chemotherapy were collected and randomly rolled into a control group (Group C) and an intervention group (Group I). Group C received ondansetron combined with routine psychological support and counseling therapy, while Group I received a combination of ondansetron, dexamethasone, promethazine hydrochloride, and psychological care therapy. Self-assessment scores for anxiety, QoL ratings, white blood cell counts, and incidence of adverse reactions were assessed and compared between the two groups.

Results: Group I showed better control of nausea and vomiting versus Group C (P< 0.05). Marked improvements were also observed in the self-rating anxiety scale (SAS) scores, white blood cell counts, and nursing satisfaction in Group I versus Group C (P< 0.05). Nevertheless, the two groups had no significant difference regarding QoL scores (P> 0.05).

Conclusion: the combination of psychological care with ondansetron, dexamethasone, and promethazine hydrochloride effectively controls nausea and vomiting symptoms in BC patients undergoing chemotherapy and provides higher levels of clinical nursing satisfaction.

Keywords: Chemotherapy for breast cancer; dexamethasone; ondansetron; promethazine hydrochloride; psychological nursing.

PubMed Disclaimer

Conflict of interest statement

Authors do not have any conflicts.

Figures

Figure 1.
Figure 1.
Comparison of therapeutic effects of nausea.
Figure 2.
Figure 2.
Comparison of therapeutic effects of vomiting.
Figure 3.
Figure 3.
Comparison of overall treatment response rate.
Figure 4.
Figure 4.
Comparison of SAS scores. Note: *P< 0.05 of SAS score vs. group C.
Figure 5.
Figure 5.
Comparison of white blood cell count. Note: *P< 0.05 of white blood cell count vs. group C.
Figure 6.
Figure 6.
Comparison of QoL scores in Group C.
Figure 7.
Figure 7.
Comparison of QoL scores in Group I.
Figure 8.
Figure 8.
Comparison of nursing satisfaction.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Hanker AB, Sudhan DR, Arteaga CL. Overcoming Endocrine Resistance in Breast Cancer. Cancer Cell. 2020. Apr 13; 37(4): 496-513. doi: 10.1016/j.ccell.2020.03.009. PMID: 32289273; PMCID: PMC7169993. - DOI - PMC - PubMed
    1. Burstein HJ, Curigliano G, Thürlimann B, Weber WP, Poortmans P, Regan MM, Senn HJ, Winer EP, Gnant M. Panelists of the St Gallen Consensus Conference. Customizing local and systemic therapies for women with early breast cancer: the St. Gallen International Consensus Guidelines for treatment of early breast cancer 2021. Ann Oncol. 2021. Oct; 32(10): 1216-1235. doi: 10.1016/j.annonc.2021.06.023. Epub 2021 Jul 6. PMID: 34242744; PMCID: PMC9906308. - DOI - PMC - PubMed
    1. Wilkinson L, Gathani T. Understanding breast cancer as a global health concern. Br J Radiol. 2022. Feb 1; 95(1130): 20211033. doi: 10.1259/bjr.20211033. Epub 2021 Dec 14. PMID: 34905391; PMCID: PMC8822551. - DOI - PMC - PubMed
    1. Kashyap D, Pal D, Sharma R, Garg VK, Goel N, Koundal D, Zaguia A, Koundal S, Belay A. Global Increase in Breast Cancer Incidence: Risk Factors and Preventive Measures. Biomed Res Int. 2022. Apr 18; 2022: 9605439. doi: 10.1155/2022/9605439. PMID: 35480139; PMCID: PMC9038417. - DOI - PMC - PubMed
    1. Montemurro F, Nuzzolese I, Ponzone R. Neoadjuvant or adjuvant chemotherapy in early breast cancer? Expert Opin Pharmacother. 2020. Jun; 21(9): 1071-1082. doi: 10.1080/14656566.2020.1746273. Epub 2020 Apr 1. PMID: 32237920. - DOI - PubMed

Publication types

MeSH terms

LinkOut - more resources