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Review
. 2025 Mar;57(3):875-884.
doi: 10.1007/s11255-024-04258-4. Epub 2024 Nov 9.

Mesenchymal stem cell-derived exosomes in renal ischemia-reperfusion injury: a new therapeutic strategy

Bo Zhao #  1   2   3 , Zhenwang Zhang #  1 , Xiying Guo #  1 , Xiufen Liu #  1 , Min Lei  1 , Shuang Guo  1 , Qing Yao  1 , Feixue Zhang  1 , Tie Peng  1 , Aimei Liu  4 , Botao Jiang  5 , Dan Zhu  6   7
Affiliations
Review

Mesenchymal stem cell-derived exosomes in renal ischemia-reperfusion injury: a new therapeutic strategy

Bo Zhao et al. Int Urol Nephrol. 2025 Mar.

Abstract

Renal ischemia-reperfusion injury (RIRI) is a serious kidney condition that causes significant damage due to lack of blood flow. This injury leads to oxidative stress and inflammation, which can cause acute tubular necrosis and kidney failure. Stem cell-derived exosomes, small vesicles released by stem cells, have shown promise in treating RIRI. Mesenchymal stem cells (MSCs) have been used to mitigate RIRI, and their exosomes have been found to play a crucial role in repairing damaged tissues. This review explores the key roles of exosomes from different sources of MSCs in RIRI, the potential of MSC-derived exosomes in treating this disease, and future research directions.

Keywords: Exosomes; Mesenchymal stem cells; RIRI; Stem cells; Therapy.

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Conflict of interest statement

Declarations. Conflict of interest: The authors declare no competing interests. Ethics approval: Not applicable. Consent for publication: Not applicable.

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