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. 2025 Feb;66(2):279-288.
doi: 10.1080/10428194.2024.2422844. Epub 2024 Nov 9.

Improvement in quality of life in MDS patients who become transfusion independent after treatment

Bo A Wan  1   2 , Shabbir M H Alibhai  3 , Lisa Chodirker  1 , Lee Mozessohn  1 , Michelle Geddes  4 , Nancy Zhu  5 , Amy M Trottier  6 , Eve St-Hilaire  7 , Nicholas Finn  7 , Brian Leber  8 , Dina Khalaf  8 , Grace Christou  9 , Mitchell Sabloff  9 , Heather A Leitch  10 , April Shamy  11 , Karen W L Yee  12 , John Storring  13 , Thomas J Nevill  14 , Brett L Houston  15 , Mohamed Elemary  16 , Robert Delage  17 , Anne Parmentier  18 , Mohammad Siddiqui  18 , Alexandre Mamedov  18 , Liying Zhang  1 , Rena Buckstein  1
Affiliations

Improvement in quality of life in MDS patients who become transfusion independent after treatment

Bo A Wan et al. Leuk Lymphoma. 2025 Feb.

Abstract

Myelodysplastic syndromes (MDSs) treatment focuses on improving quality of life (QOL), affected by anemia and transfusion dependence (TD). Using the MDS-CAN registry, we studied how changes in transfusion status - TD to transfusion independence (TI) (group A), or vice versa (group B), and maintaining TD (group C) or TI (group D) - affected OS and QOL in 1120 MDS patients. Analysis showed superior OS for those remaining TI, poorer for those remaining TD, and intermediate for those with changes. Among 656 treated patients, group A (n = 54) showed improved QOL, with trends toward improved physical and social function scores. Group B (n = 151) experienced declines in global QOL measures after switching to TD, particularly in fatigue and physical, role, and social functioning. Group C had notable fatigue worsening, while group D showed milder declines across multiple QOL aspects. Achieving TI in MDS correlates with improved QOL, whereas reverting to TD more significantly worsens overall QOL and function scores.

Keywords: Myelodysplastic syndromes; hypomethylating agent; quality of life; transfusion status.

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