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Clinical Trial
. 2024 Nov 8;5(11):1340-1341.
doi: 10.1016/j.medj.2024.09.008.

ARCADIA trials: Can nemolizumab be a valid alternative to the therapies currently available?

Maddalena Napolitano  1 , Cataldo Patruno  2
Affiliations
Clinical Trial

ARCADIA trials: Can nemolizumab be a valid alternative to the therapies currently available?

Maddalena Napolitano et al. Med. .

Abstract

ARCADIA 1 and ARCADIA 2 were two randomized, placebo-controlled phase 3 trials showing the effectiveness of nemolizumab with concomitant use of low-to-medium potency topical corticosteroids, and/or with or without topical calcineurin inhibitors, in adults and adolescents with moderate-to-severe atopic dermatitis. Coprimary endpoints were met in the nemolizumab plus background therapy groups in both trials, with significant differences versus placebo.

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Conflict of interest statement

Declaration of interests M.N. reports consulting fees from Abbvie, Lilly, LEO Pharma, Almirall, Sanofi; payment/honoraria from Abbvie, Lilly, LEO Pharma, Almirall, Sanofi; participation on Data Safety Monitoring Board/Advisory Board from Lilly, Sanofi, LEO Pharma, Abbvie, and Almirall; support for attending meetings/travel from Lilly, Abbvie, Sanofi. C.P. has been principal investigator in clinical trials sponsored by and/or and has received personal fees from AbbVie, Almirall, Celgene, LeoPharma, Novartis, Pfizer, Parexel, Sanofi, Janssen, Lilly.

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