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Randomized Controlled Trial
. 2025 Feb:277:114391.
doi: 10.1016/j.jpeds.2024.114391. Epub 2024 Nov 8.

Respiratory Outcomes of Infants Born Extremely Preterm in the Necrotizing Enterocolitis Surgery Trial

Sara B DeMauro  1 , Erik A Jensen  2 , Scott A McDonald  3 , Susan Hintz  4 , Jon Tyson  5 , David K Stevenson  4 , Martin L Blakely  5 ; NICHD Neonatal Research Network
Collaborators, Affiliations
Randomized Controlled Trial

Respiratory Outcomes of Infants Born Extremely Preterm in the Necrotizing Enterocolitis Surgery Trial

Sara B DeMauro et al. J Pediatr. 2025 Feb.

Abstract

The multicenter Necrotizing Enterocolitis Surgery Trial compared initial peritoneal drainage with laparotomy among infants with extremely low birth weight and surgical necrotizing enterocolitis or intestinal perforation. In this post hoc analysis of trial data, initial drainage was associated with adverse respiratory outcomes, both in hospital and through 2 years corrected age.

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Conflict of interest statement

Declaration of Competing Interest The National Institutes of Health and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (U10 HD27871, U10 HD53119, UG1 HD21364, UG1 HD21373, UG1 HD21385, UG1 HD27851, UG1 HD27853, UG1 HD27856, UG1 HD27880,UG1 HD27904, UG1 HD34216, UG1 HD36790, UG1 HD40492, UG1 HD40689, UG1 HD53089, UG1 HD53109, UG1 HD68244, UG1 HD68270, UG1 HD68278, UG1 HD68263, UG1 HD68284, UG1 HD87226, UG1 HD87229) and the National Center for Advancing Translational Sciences (NCATS) (UL1 TR6, UL1 TR41, UL1 TR42, UL1 TR77, UL1 TR93, UL1 TR442, UL1 TR454, UL1 TR1117) provided grant support through cooperative agreements for the Neonatal Research Network’s Necrotizing Enterocolitis Surgery Trial (NEST). While NICHD staff had input into the trial design, conduct, analysis, and manuscript drafting, the comments and views of the authors do not necessarily represent the views of NICHD, the National Institutes of Health, the Department of Health and Human Services, or the U.S. Government. The authors have no conflicts of interest to declare.

References

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