Evidence for an HPV one-dose schedule

Margaret Stanley¹, Anne Schuind², Kirthini K Muralidharan³, Dominique Guillaume⁴, Victoria Willens⁵, Hannah Borda⁵, Marley Jurgensmeyer⁵, Rupali Limaye⁶

Affiliations

¹ Department of Pathology, University of Cambridge, Tennis Court Rd, Cambridge, CB2 1QP, United Kingdom.
² PATH, USA.
³ International Vaccine Access Center at the Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of International Health, Division of Global Disease Epidemiology and Control, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD, 21205, USA; Coalition to Strengthen the HPV Immunization Community (CHIC), USA. Electronic address: kmuralidharan@jhu.edu.
⁴ International Vaccine Access Center at the Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Coalition to Strengthen the HPV Immunization Community (CHIC), USA; School of Nursing, Johns Hopkins University, 525 N Wolfe St, Baltimore, MD, 21205, USA.
⁵ International Vaccine Access Center at the Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of International Health, Division of Global Disease Epidemiology and Control, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD, 21205, USA; Coalition to Strengthen the HPV Immunization Community (CHIC), USA.
⁶ International Vaccine Access Center at the Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of International Health, Division of Global Disease Epidemiology and Control, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD, 21205, USA; Coalition to Strengthen the HPV Immunization Community (CHIC), USA; Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD, 21205, USA; Department of Epidemiology, Division of Infectious Disease Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD, 21205, USA.

PMID: 39521566
DOI: 10.1016/j.vaccine.2024.01.046

Free article

Review

Evidence for an HPV one-dose schedule

Margaret Stanley et al. Vaccine. 2024.

Free article

. 2024 Jul 11:42 Suppl 2:S16-S21.

doi: 10.1016/j.vaccine.2024.01.046. Epub 2024 Nov 7.

Authors

Margaret Stanley¹, Anne Schuind², Kirthini K Muralidharan³, Dominique Guillaume⁴, Victoria Willens⁵, Hannah Borda⁵, Marley Jurgensmeyer⁵, Rupali Limaye⁶

Affiliations

¹ Department of Pathology, University of Cambridge, Tennis Court Rd, Cambridge, CB2 1QP, United Kingdom.
² PATH, USA.
³ International Vaccine Access Center at the Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of International Health, Division of Global Disease Epidemiology and Control, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD, 21205, USA; Coalition to Strengthen the HPV Immunization Community (CHIC), USA. Electronic address: kmuralidharan@jhu.edu.
⁴ International Vaccine Access Center at the Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Coalition to Strengthen the HPV Immunization Community (CHIC), USA; School of Nursing, Johns Hopkins University, 525 N Wolfe St, Baltimore, MD, 21205, USA.
⁵ International Vaccine Access Center at the Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of International Health, Division of Global Disease Epidemiology and Control, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD, 21205, USA; Coalition to Strengthen the HPV Immunization Community (CHIC), USA.
⁶ International Vaccine Access Center at the Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of International Health, Division of Global Disease Epidemiology and Control, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD, 21205, USA; Coalition to Strengthen the HPV Immunization Community (CHIC), USA; Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD, 21205, USA; Department of Epidemiology, Division of Infectious Disease Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD, 21205, USA.

PMID: 39521566
DOI: 10.1016/j.vaccine.2024.01.046

Abstract

The World Health Organization has recently updated their dosing schedule recommendations for the human papillomavirus (HPV) vaccine to include a single-dose schedule. We review the biologic plausibility of a single dose, the evidence from clinical trials, post-licensure observational studies, and mathematical modeling for a single-dose schedule. We also discuss the implications of countries switching to a single-dose program from a two or three-dose schedule. Finally, we review the countries that have currently switched to or introduced the vaccine with a single-dose schedule.

Keywords: Dosing Schedule; HPV Vaccine; Immunisation Programmes.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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Evidence for an HPV one-dose schedule

Affiliations

Evidence for an HPV one-dose schedule

Authors

Affiliations

Abstract

Conflict of interest statement

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MeSH terms

Substances

LinkOut - more resources

Full Text Sources