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Case Reports
. 2024 Nov 9;25(1):403.
doi: 10.1186/s12882-024-03801-w.

Gitelman syndrome patient managed with amiloride during pregnancy and lactation

Abdelrahman Ibrahim  1 , Aylin R Rodan  1 , Christof Westenfelder  1 , Laith Al-Rabadi  2
Affiliations
Case Reports

Gitelman syndrome patient managed with amiloride during pregnancy and lactation

Abdelrahman Ibrahim et al. BMC Nephrol. .

Abstract

Gitelman Syndrome (GS) is a rare autosomal-recessive tubular disorder characterized by hypokalemia, hypomagnesemia, metabolic alkalosis, hyperreninemic hyperaldosteronism, and normotension. Management of GS during pregnancy is particularly challenging due to pregnancy-associated renal physiological changes and due to controversial safety profiles regarding teratogenicity of medications commonly used for GS management in non-pregnant patients. We report a case of a 20-year-old female patient diagnosed of GS who was treated with amiloride during pregnancy and lactation due to persistent hypokalemia resistant to oral supplementation therapy. Use of amiloride facilitated control of hypokalemia and hypomagnesemia in the mother without causing any noticeable side effects in the newborn.

Keywords: Amiloride; Gitelman; Hypokalemia; Hypomagnesemia; Pregnancy.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Maternal serum potassium and magnesium levels during pregnancy and breastfeeding in correlation with amiloride treatment
See this image and copyright information in PMC

References

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