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. 2024 Nov 9;17(1):332.
doi: 10.1186/s13104-024-06992-5.

Predictive haemostatic biomarkers and transfusion efficacy, insights from fresh frozen plasma use in surgical patients, preliminary results

Olivier Duranteau  1   2   3 , Justine Decamps  4 , Anne Daper  4 , Philippe Cauchie  5 , Brigitte Ickx  6 , Turgay Tuna  6
Affiliations

Predictive haemostatic biomarkers and transfusion efficacy, insights from fresh frozen plasma use in surgical patients, preliminary results

Olivier Duranteau et al. BMC Res Notes. .

Abstract

The aim of the study was to examine various haemostasis values to identify the most relevant biological indicators for detecting significant haemorrhage, to determine the effectiveness of fresh frozen plasma (FFP) transfusion. Our findings suggest that a low prothrombin time, elevated Von Willebrand Antigen, increased plasma fibrinogen, and reduced Ca2 + levels are associated with challenges in achieving proper haemostasis. However, measurements of factors II, V, VII, VIII, IX, X, XI, XIII, protein C, and protein S do not appear to be linked to difficulties in achieving adequate haemostasis. Additionally, the administration of FFP appears to impact factors V, VII, X, and II.Trial registration EudraCT number: 2019-002898-64.

Keywords: Fresh frozen plasma; Haemostasis; Transfusion threshold; Transfusion yield.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Biologic values evolution during the surgery. Lactates blood lactate (mmol/L), Ca2 + blood ionized calcium (mmol/L), Hb Haemoglobin (g/dL), vWF:Ag von Willebrand factor level, antigen (%), vWF:RCof von Willebrand factor activity, Ristocetin cofactor (%), PT Prothrombin Time (%), APTT activated partial thromboplastin time (sec), INR International Normalised Ratio, Fibrinogen Fibrinogen plasma level (g/L), TT Thrombin time (sec). Factor II: blood Factor II (%), Factor V: blood Factor V (%), Factor VII: blood Factor VII (%), Factor VIII: blood Factor VIII (%), Factor IX: blood Factor IX (%), Factor X: blood Factor X (%), Factor XI: blood Factor XI (%), Factor XIII: blood Factor XIII (%), Protein C: blood protein C (%), Protein S: blood protein S (%)
Fig. 1
Fig. 1
Biologic values evolution during the surgery. Lactates blood lactate (mmol/L), Ca2 + blood ionized calcium (mmol/L), Hb Haemoglobin (g/dL), vWF:Ag von Willebrand factor level, antigen (%), vWF:RCof von Willebrand factor activity, Ristocetin cofactor (%), PT Prothrombin Time (%), APTT activated partial thromboplastin time (sec), INR International Normalised Ratio, Fibrinogen Fibrinogen plasma level (g/L), TT Thrombin time (sec). Factor II: blood Factor II (%), Factor V: blood Factor V (%), Factor VII: blood Factor VII (%), Factor VIII: blood Factor VIII (%), Factor IX: blood Factor IX (%), Factor X: blood Factor X (%), Factor XI: blood Factor XI (%), Factor XIII: blood Factor XIII (%), Protein C: blood protein C (%), Protein S: blood protein S (%)
Fig. 1
Fig. 1
Biologic values evolution during the surgery. Lactates blood lactate (mmol/L), Ca2 + blood ionized calcium (mmol/L), Hb Haemoglobin (g/dL), vWF:Ag von Willebrand factor level, antigen (%), vWF:RCof von Willebrand factor activity, Ristocetin cofactor (%), PT Prothrombin Time (%), APTT activated partial thromboplastin time (sec), INR International Normalised Ratio, Fibrinogen Fibrinogen plasma level (g/L), TT Thrombin time (sec). Factor II: blood Factor II (%), Factor V: blood Factor V (%), Factor VII: blood Factor VII (%), Factor VIII: blood Factor VIII (%), Factor IX: blood Factor IX (%), Factor X: blood Factor X (%), Factor XI: blood Factor XI (%), Factor XIII: blood Factor XIII (%), Protein C: blood protein C (%), Protein S: blood protein S (%)
Fig. 1
Fig. 1
Biologic values evolution during the surgery. Lactates blood lactate (mmol/L), Ca2 + blood ionized calcium (mmol/L), Hb Haemoglobin (g/dL), vWF:Ag von Willebrand factor level, antigen (%), vWF:RCof von Willebrand factor activity, Ristocetin cofactor (%), PT Prothrombin Time (%), APTT activated partial thromboplastin time (sec), INR International Normalised Ratio, Fibrinogen Fibrinogen plasma level (g/L), TT Thrombin time (sec). Factor II: blood Factor II (%), Factor V: blood Factor V (%), Factor VII: blood Factor VII (%), Factor VIII: blood Factor VIII (%), Factor IX: blood Factor IX (%), Factor X: blood Factor X (%), Factor XI: blood Factor XI (%), Factor XIII: blood Factor XIII (%), Protein C: blood protein C (%), Protein S: blood protein S (%)
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