Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Nov 11;30(1):207.
doi: 10.1186/s10020-024-00967-9.

Mesenchymal stem cells lineage and their role in disease development

Qi Xu #  1 , Wenrun Hou #  1 , Baorui Zhao  2 , Peixin Fan  1 , Sheng Wang  1 , Lei Wang  1 , Jinfang Gao  3
Affiliations
Review

Mesenchymal stem cells lineage and their role in disease development

Qi Xu et al. Mol Med. .

Abstract

Mesenchymal stem cells (MSCs) are widely dispersed in vivo and are isolated from several tissues, including bone marrow, heart, body fluids, skin, and perinatal tissues. Bone marrow MSCs have a multidirectional differentiation potential, which can be induced to differentiate the medium in a specific direction or by adding specific regulatory factors. MSCs repair damaged tissues through lineage differentiation, and the ex vivo transplantation of bone marrow MSCs can heal injured sites. MSCs have different propensities for lineage differentiation and pathological evolution for different diseases, which are crucial in disease progression. In this study, we describe various lineage analysis methods to explore lineage ontology in vitro and in vivo, elucidate the impact of MSC lineage differentiation on diseases, advance our understanding of the role of MSC differentiation in physiological and pathological states, and explore new targets and ideas associated with disease diagnosis and treatment.

Keywords: Differentiation potential; Lineage genesis; Mesenchymal stem cells; Osteoarthritis; Rheumatoid arthritis.

PubMed Disclaimer

Conflict of interest statement

Declarations Ethics approval and consent to participate Not applicable. Consent for publication Not applicable. Competing interests The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Lineage tracking diagram. (A) Labelling of cell clusters with chemical dyes and genealogical tracing to embryonic cells; (B) Lineage tracking by markers in the cytoplasm; (C) Lineage tracking by markers in the nucleus; (D) Single-cell lineage tracing
Fig. 2
Fig. 2
The application of MSCs transplantation in cell therapy. (A) Statistical analysis of clinical trials from different tissue sources retrieved on clinicaltrial.gov identifier; (B) MSC transplantation and differentiation therapy for various systemic diseases. DP: dental pulp ; BM: bone marrow; UC: umbilical cord; AT: adipose tissue; SM: synovial membrane; COPD: chronic obstructive pulmoriary disease
Fig. 3
Fig. 3
Spectral differentiation of MSCs in disease. Top left: Pathogenesis of MSCs in joint diseases. Top right: Pathogenesis of MSCs in fibrotic disease. Bottom left: Pathogenesis of MSCs in hematological diseases. Bottom right: The pathogenic mechanism of MSCs in tumor diseases. MM cells: Multiple myeloma cells; MDS cells: Myelodysplastic syndrome cells; EVs: Extracellular vesicles; CA-MSC: Carcinoma-associated mesenchymal stem cells
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Abbas MA, Boby N, Lee EB, Hong JH, Park SC. Anti - obesity effects of ecklonia cava extract in high - fat diet - induced obese rats. Antioxidants. 2022;11(2):310. - PMC - PubMed
    1. Anjos - Afonso F, Siapati EK, Bonnet D. In vivo contribution of murine mesenchymal stem cells into multiple cell - types under minimal damage conditions. J Cell Sci. 2004;117(Pt 23):5655–64. - PubMed
    1. Azargoon A, Negahdari B. Lung regeneration using amniotic fluid mesenchymal stem cells. Artif Cells Nanomed Biotechnol. 2018;46(3):447–51. - PubMed
    1. Banas A, Teratani T, Yamamoto Y, Tokuhara M, Takeshita F, Quinn G, et al. Adipose tissue - derived mesenchymal stem cells as a source of human hepatocytes. Hepatology. 2007;46(1):219–28. - PubMed
    1. Baron CS, van Oudenaarden A. Unravelling cellular relationships during development and regeneration using genetic lineage tracing. Nat Rev Mol Cell Biol. 2019;20(12):753–65. - PubMed

LinkOut - more resources