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Randomized Controlled Trial
. 2024 Nov 10;24(1):1366.
doi: 10.1186/s12903-024-05161-1.

Postobturation Pain of three Novel Calcium Silicate-based sealers with asymptomatic irreversible pulpitis or necrotic pulp with chronic apical periodontitis: prospective clinical trial

Ali Turkyilmaz  1 , Sevda Durust Baris  2 , Dilek Hancerliogullari  2 , Ali Erdemir  2
Affiliations
Randomized Controlled Trial

Postobturation Pain of three Novel Calcium Silicate-based sealers with asymptomatic irreversible pulpitis or necrotic pulp with chronic apical periodontitis: prospective clinical trial

Ali Turkyilmaz et al. BMC Oral Health. .

Abstract

Background: Bioceramic-based root canal sealers are increasingly important in root canal treatment because of their biocompatible properties. This study aimed to evaluate postobturation pain incidence and intensity after root canal obturation with NeoSealer Flo, MTA-Bioseal, and GuttaFlow bioseal calcium silicate-based sealers and AH Plus epoxy resin-based sealer in patients with asymptomatic irreversible pulpitis or necrotic pulp with chronic apical periodontitis.

Methods: A total of 120 participants with single-rooted teeth were included and randomly divided into four groups according to the root canal sealer used (n = 30). The patients were subsequently categorised based on the pulp vitality (vital or nonvital) in each group (n = 15) and all teeth were obturated in a single-visit. The postobturation pain scores were recorded on a visual analogue scale (VAS) at 6 h, 24 h, 48 h, 72 h, 7 d and 30 d. Moreover, analgesic intake was also noted at 24 h and 48 h. The Mann-Whitney U test, Kruskal‒Wallis H test, Friedman test, and Spearman's correlation test were used, and a p value < 0.05 was considered significant.

Results: VAS scores were highest for the 6 h > 24 h > 48 h ≈ 72 h ≈ 7 d ≈ 30 d time intervals for both pulp status in each root canal sealer. A significant decrease in the VAS score was observed for all sealers from 6 h to 48 h (p 0.05). Nonvital cases had lower VAS scores at all time intervals. Analgesic intake was greater in the first 24 h (p < 0.05) in vital cases (p < 0.05) and also in females than males.

Conclusion: The level of pain experienced after obturation was similar in patients with different pulp status for all the root canal sealers. Analgesic intake was greater in vital cases and females within 24 h.

Trial registration: ClinicalTrial.gov , NCT06515756, record date: 2024-07-17, retrospectively registered.

Keywords: Calcium silicate; Pain; Postobturation; Root canal sealer; Visual analogue scale.

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Conflict of interest statement

Declarations Ethics approval and consent to participate The study was approved and numbered (01.06.2023-07/06) by the Ethical Committee of the University of Kirikkale. and was registered under the protocol ID NCT06515756 (https://clinicaltrials.gov/) according to the CONSORT statement of the updated guidelines for reporting randomized clinical trials. Informed consent was taken from all participants. Consent for publication Not applicable. Competing interests The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flow chart
Fig. 2
Fig. 2
Comparison of pain levels in the root canal sealer based on pulp status
Fig. 3
Fig. 3
Comparison of pain levels according to pulp status based on the use of root canal sealers
See this image and copyright information in PMC

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