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Review
. 2024 Nov 6:19:11321-11341.
doi: 10.2147/IJN.S485588. eCollection 2024.

Collagen-Based Nanoparticles as Drug Delivery System in Wound Healing Applications

Kusnadi Kusnadi  1   2 , Yedi Herdiana  1 , Emma Rochima  3 , Okta Nama Putra  1   4 , Amirah Mohd Gazzali  5 , Muchtaridi Muchtaridi  1   6
Affiliations
Review

Collagen-Based Nanoparticles as Drug Delivery System in Wound Healing Applications

Kusnadi Kusnadi et al. Int J Nanomedicine. .

Abstract

Background: Conventional wound dressings often adhere to wounds and can cause secondary injury due to their lack of anti-inflammatory and antibacterial properties. In contrast, collagen-based nanoparticles (NPs) as drug delivery systems exhibit both biocompatibility and biodegradability, presenting a promising avenue for accelerating wound healing processes.

Aims of study: This review aims to provide a comprehensive overview of the mechanisms involved in wound healing, description of the attributes of ideal wound dressings, understanding of wound healing efficacy of collagen, exploring NPs-mediated drug delivery mechanisms in wound therapy, detailing the synthesis and fabrication techniques of collagen-based NPs, and delineating the applications of various collagen-based NPs infused wound dressings on wound healing.

Methodology: This review synthesizes relevant literature from reputable databases such as Scopus, Science Direct, Google Scholar, and PubMed.

Results: A diverse array of collagen-based NPs, including nanopolymers, metal NPs, nanoemulsions, nanoliposomes, and nanofibers, demonstrate pronounced efficacy in promoting wound closure and tissue regeneration. The incorporation of collagen-based NPs has not only become an agent for the delivery of therapeutics but also actively contributes to the wound healing cascade.

Conclusion: In conclusion, In brief, the use of collagen-based NPs presents a compelling strategy for expediting wound healing processes.

Keywords: biodegradability; collagen; fabrication techniques; nanoparticles; wound healing.

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Conflict of interest statement

The authors declare that there are no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Flowchart illustrating the methodology employed in this review.
Figure 2
Figure 2
A diagram illustrating the primary stages of the wound healing process.
Figure 3
Figure 3
Development and characteristics of wound dressings. The advantages and disadvantages of various dressings are outlined in green and orange squares, respectively.
Figure 4
Figure 4
Molecular structure of collagen type I.
Figure 5
Figure 5
Summary of the healing attributes facilitated by collagen.
Figure 6
Figure 6
Overview of the application of NPs for wound healing.
Figure 7
Figure 7
Different collagen-based NPs drug delivery systems in wound healing applications.
Figure 8
Figure 8
The illustration of the application of collagen-based NPs for wound healing.
See this image and copyright information in PMC

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