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. 1979 Feb;237(2):267-74.

Effects of halopemide, a new psychotropic agent, on the uptake of serotonin by blood platelets

A J Loonen, W Soudijn
  • PMID: 39525

Effects of halopemide, a new psychotropic agent, on the uptake of serotonin by blood platelets

A J Loonen et al. Arch Int Pharmacodyn Ther. 1979 Feb.

Abstract

The influence of halopemide, a new psychotropic agent, and some putative metabolites on the uptake of 14C-5-HT into blood platelets of rat and man were studied and compared to the effects of imipramine, sulpiride and clozapine. Halopemide, its putative metabolites R 38570 and R 29676 and sulpiride inhibited the uptake in a dose-dependent manner, but the compounds were less active than imipramine. Clozapine and p-fluorohippuric acid, another putative metabolite of halopemide, were totally devoid of activity.

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