Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2024 Oct 11;16(10):e71252.
doi: 10.7759/cureus.71252. eCollection 2024 Oct.

Aseptic Meningitis as an Initial Presentation of Primary Sjögren's Syndrome: A Case Report

Sara Alnajjar  1 , Jumanah Alfuwayris  2 , Abdulmajid M Al Arfaj  3 , Abdulmohsen Almukhaitah  1 , Munirah Almakhayitah  4 , Naimah A Al-Naim  4 , Reem Alharshan  1
Affiliations
Case Reports

Aseptic Meningitis as an Initial Presentation of Primary Sjögren's Syndrome: A Case Report

Sara Alnajjar et al. Cureus. .

Abstract

Neurological symptoms that occur before the diagnosis of primary Sjögren's syndrome (PSS) can vary and affect either the central nervous system (CNS) or the peripheral nervous system (PNS). Aseptic meningitis, although rare, can be an initial central neurological sign of PSS. This case report describes a 54-year-old patient who was initially presented with aseptic meningitis and was subsequently diagnosed with PSS. The diagnosis was based on clinical features and the results of serum autoantibody tests. The patient did not undergo a minor salivary gland biopsy to confirm the diagnosis. Symptomatic management resulted in an improvement in the patient's condition.

Keywords: aseptic meningitis; autoimmune diseases; dry eye and mouth; headache; primary sjogren’s syndrome; sjögren's syndrome.

PubMed Disclaimer

Conflict of interest statement

Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. Brain magnetic resonance imaging.
Brain MRI T2 fluid-attenuated inversion recovery sequence sagittal (A) and axial (B) views showed partially empty sella turcica and prominent subarachnoid space around the optic nerve.
Figure 2
Figure 2. Brain magnetic resonance imaging.
Brain MRI T2 fluid-attenuated inversion recovery sequence on gadolinium-enhanced axial views (A and B) revealed leptomeningeal enhancement along the bifrontal lobes and the left Sylvian fissure.
Figure 3
Figure 3. Brain magnetic resonance venography was unremarkable.
See this image and copyright information in PMC

References

    1. Aseptic meningitis as an initial manifestation of primary Sjögren's syndrome. Higashida-Konishi M, Akiyama M, Shimada T, et al. Mod Rheumatol Case Rep. 2023;7:388–393. - PubMed
    1. Primary Sjögren’s syndrome presenting as recurrent ischemic strokes. Kesav P, Hussain SI, Devnani P, et al. Neurohospitalist. 2022;12:341–345. - PMC - PubMed
    1. Meningitis as a complication of Sjögren's syndrome. Corrêa DG, Hygino da Cruz LC Jr. https://pubmed.ncbi.nlm.nih.gov/36270916/ Clin Imaging. 2023;93:113–114. - PubMed
    1. Neurologic manifestations of primary Sjögren syndrome. Margaretten M. Rheum Dis Clin North Am. 2017;43:519–529. - PubMed
    1. Primary Sjögren's syndrome: central and peripheral nervous system involvements. Mekinian A, Tennenbaum J, Lahuna C, et al. https://pubmed.ncbi.nlm.nih.gov/33095149/ Clin Exp Rheumatol. 2020;38:103–109. - PubMed

Publication types

LinkOut - more resources