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. 2024 Dec 1;93(6):658-663.
doi: 10.1097/SAP.0000000000004136.

Facial Artery Branch Thrombolysis for Nasal Vascular Embolism Induced by Hyaluronic Acid Injection

Hong Yang  1 , Yan Zheng  1 , Dan Li  2 , Tian-Zhu Li  2 , Jian-Hui Zhao  3 , Kai-Yi Shu  2 , Li-Li Cao  1 , Tian-Lin Guo  1 , Fei-Lun Ye  1
Affiliations

Facial Artery Branch Thrombolysis for Nasal Vascular Embolism Induced by Hyaluronic Acid Injection

Hong Yang et al. Ann Plast Surg. .

Abstract

Background: Vascular embolism is a severe complication following hyaluronic acid (HA) filler injections, with hyaluronidase injection being the most effective treatment. The nasal region, including the nose and nasolabial fold, is the most common site of vascular embolism after facial HA injections. Currently, there is insufficient clinical evidence regarding the benefits of facial artery thrombolysis.

Objectives: This article aimed to evaluate the efficacy of hyaluronidase injection via the facial artery as an emergency treatment for vascular embolism induced by facial aesthetic HA fillers.

Methods: We reviewed 14 patients who experienced nasal vascular embolism following facial HA filler injections. All 14 patients underwent percutaneous facial artery thrombolysis with a combination of hyaluronidase and urokinase administered intravascularly. For patients with longer occlusion duration and severe necrosis, femoral artery interventional thrombolysis was performed, with local injection of platelet-rich plasma to promote recovery. Follow-up ranged from 1 month to 1 year.

Results: Following facial artery hyaluronidase injection, all cases showed improvement in nasal skin lesions. Twelve patients fully recovered, while 2 patients were left with minor superficial scars and defects in the nasal wings.

Conclusions: Early thrombolysis postnasal embolism is crucial, and percutaneous facial artery puncture is an effective emergency treatment. Arterial intervention targeting the facial artery in the nasolabial fold may offer more precise thrombolysis. The combined use of hyaluronidase and urokinase is both safe and effective.

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Conflict of interest statement

Conflicts of interest and sources of funding: none declared.

References

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    1. Soares DJ, Hynes SD, Yi CH, et al. Cosmetic filler-induced vascular occlusion: a rising threat presenting to emergency departments. Ann Emerg Med . 2024;83:59–67.

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