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. 2024 Nov 20;146(46):31412-31419.
doi: 10.1021/jacs.4c11758. Epub 2024 Nov 11.

Oxoammonium-Catalyzed Oxidation of N-Substituted Amines

Jonas Rein  1 , Bartosz Górski  1 , Yukun Cheng  1 , Zhen Lei  2 , Frederic Buono  2 , Song Lin  1
Affiliations

Oxoammonium-Catalyzed Oxidation of N-Substituted Amines

Jonas Rein et al. J Am Chem Soc. .

Abstract

We report the development of oxoammonium-catalyzed oxidation of N-substituted amines via a hydride transfer mechanism. Steric and electronic tuning of catalyst led to complementary sets of conditions that can oxidize a broad scope of carbamates, sulfonamides, ureas, and amides into the corresponding imides. The reaction was further demonstrated on a 100-g scale using a continuous flow setup.

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