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Comparative Study
. 2024 Nov;7(6):e70011.
doi: 10.1002/edm2.70011.

Assessment of Serum FABP-4 Levels in Hypothyroidism Patients: A Comparative Analysis With a Control Group and Their Correlation With Liver Function Tests and Biochemical Factors

Mundher Mohammad Hamzeh Aldulaimi  1 , Afsaneh Shafiei  1   2 , Somayeh Ghorbani  3 , Fatima Mohammadzadeh  1   2 , Safoura Khajeniazi  1   2
Affiliations
Comparative Study

Assessment of Serum FABP-4 Levels in Hypothyroidism Patients: A Comparative Analysis With a Control Group and Their Correlation With Liver Function Tests and Biochemical Factors

Mundher Mohammad Hamzeh Aldulaimi et al. Endocrinol Diabetes Metab. 2024 Nov.

Abstract

Background: The association of serum FABP4 and other biochemical-related parameters is important to determine complications of hypothyroidism. This study aimed to evaluate serum FABP-4 levels in hypothyroidism patients in comparison with a control group.

Materials and methods: Forty-five patients with hypothyroidism and 45 healthy volunteers were included in this study. Liver function tests, thyroid hormones panel, lipid profile and serum FABP-4 levels were measured and compared in both groups, and their correlations were analysed.

Results: Serum FABP-4 levels were significantly higher in patients with hypothyroidism compared to the control group (p = 0.002), and serum FABP-4 level in males was higher than it in females (p = 0.022). There was a significant difference between patients with hypothyroidism and the control group in the levels of AST (p = 0.012). Moreover, serum FABP-4 levels were negatively correlated with age (p = 0.016) and positively correlated with weight (p = 0.044).

Conclusion: In our study, there was a notable increase in serum FABP-4 concentration among hypothyroidism subjects. The data suggest that FABP-4 could potentially be a superior diagnostic indicator for hypothyroidism when contrasted with a control cohort in future studies.

Keywords: FABP‐4; adipokine; hypothyroidism; lipid profile; thyroid hormones.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Levels of FABP4 in Control and Patients with hypothyroidism, **p < 0.05.
See this image and copyright information in PMC

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