[Mutation process and malignant transformation induced by adenoviruses in mammalian cells]
[Article in
Russian]
- PMID: 3952810
Item in Clipboard
[Mutation process and malignant transformation induced by adenoviruses in mammalian cells]
[Article in
Russian]
Tsitol Genet.
1986 Jan-Feb.
Abstract
Both oncogenic adenovirus (BAV-3) and nononcogenic adenovirus (Ad-1) are able to induce gene mutations in cultured mammalian cells. In the case of equal multiplicity of the infection the frequency of induced mutations is higher in variants with Ad-1. Unlike Ad-1 both mutagenic and transforming effects of BAV-3 are intensified by means of TPA promoters. TPA modifies analogously mutagenic and transforming effect of much less than oncogenic fragment much greater than of DNA BAV-3. Oncogene and, probably, other viral genes reveal mutagenic activity.
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