Genetically determined telomere length in monoclonal gammopathy of undetermined significance, multiple myeloma risk and outcome

Matteo Giaccherini^#¹, Alyssa I Clay-Gilmour^#^{2

3}, Romano Liotti¹, Angelica Macauda⁴, Manuel Gentiluomo¹, Elizabeth E Brown⁵, Mitchell J Machiela⁶, Stephen J Chanock⁶, Michelle A T Hildebrandt⁷, Aaron D Norman³, Elisabet Manasanch⁷, S Vincent Rajkumar⁸, Jonathan N Hofmann⁶, Sonja I Berndt⁶, Parveen Bhatti^{9

10}, Graham G Giles^{11

12

13}, Elad Ziv¹⁴, Shaji K Kumar⁸, Nicola J Camp¹⁵, Wendy Cozen¹⁶, Susan L Slager^{8

17}, Federico Canzian⁴, Federica Gemignani^#¹, Celine M Vachon^#³, Daniele Campa^#¹⁸

Affiliations

¹ Department of Biology, University of Pisa, Pisa, Italy.
² Department of Biostatistics & Epidemiology, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
³ Division of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
⁴ Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁵ Department of Pathology, Heersink School of Medicine, University of Alabama, Birmingham, AL, USA.
⁶ Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
⁷ Division of Cancer Medicine, Department of Lymphoma - Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
⁸ Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
⁹ Cancer Control Research, BC Cancer, Vancouver, BC, Canada.
¹⁰ Program in Epidemiology, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
¹¹ Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.
¹² Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.
¹³ Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.
¹⁴ Department of Medicine, University of California San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, USA.
¹⁵ Division of Hematology and Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
¹⁶ Division of Hematology/Oncology, Department of Medicine, School of Medicine, Department of Pathology, School of Medicine, Susan and Henry Samueli College of Health Sciences, Chao Family Comprehensive Cancer Center, University of California at Irvine, Irvine, CA, USA.
¹⁷ Division of Computational Biology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
¹⁸ Department of Biology, University of Pisa, Pisa, Italy. daniele.campa@unipi.it.

^# Contributed equally.

PMID: 39528488
PMCID: PMC11554786
DOI: 10.1038/s41408-024-01181-w

Genetically determined telomere length in monoclonal gammopathy of undetermined significance, multiple myeloma risk and outcome

Matteo Giaccherini et al. Blood Cancer J. 2024.

. 2024 Nov 11;14(1):200.

doi: 10.1038/s41408-024-01181-w.

Authors

Affiliations

¹ Department of Biology, University of Pisa, Pisa, Italy.
² Department of Biostatistics & Epidemiology, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
³ Division of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
⁴ Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁵ Department of Pathology, Heersink School of Medicine, University of Alabama, Birmingham, AL, USA.
⁶ Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
⁷ Division of Cancer Medicine, Department of Lymphoma - Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
⁸ Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
⁹ Cancer Control Research, BC Cancer, Vancouver, BC, Canada.
¹⁰ Program in Epidemiology, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
¹¹ Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.
¹² Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.
¹³ Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.
¹⁴ Department of Medicine, University of California San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, USA.
¹⁵ Division of Hematology and Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
¹⁶ Division of Hematology/Oncology, Department of Medicine, School of Medicine, Department of Pathology, School of Medicine, Susan and Henry Samueli College of Health Sciences, Chao Family Comprehensive Cancer Center, University of California at Irvine, Irvine, CA, USA.
¹⁷ Division of Computational Biology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
¹⁸ Department of Biology, University of Pisa, Pisa, Italy. daniele.campa@unipi.it.

^# Contributed equally.

PMID: 39528488
PMCID: PMC11554786
DOI: 10.1038/s41408-024-01181-w

No abstract available

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Conflict of interest statement

Competing interests The authors declare no competing interests.

References

1. Giaccherini M, Gentiluomo M, Fornili M, Lucenteforte E, Baglietto L, Campa D. Association between telomere length and mitochondrial copy number and cancer risk in humans: a meta-analysis on more than 300,000 individuals. Crit Rev Oncol/Hematol. 2021;167:103510. - PubMed
1. Giaccherini M, Macauda A, Sgherza N, Sainz J, Gemignani F, Maldonado JMS, et al. Genetic polymorphisms associated with telomere length and risk of developing myeloproliferative neoplasms. Blood Cancer J. 2020;10:89. - PMC - PubMed
1. Codd V, Wang Q, Allara E, Musicha C, Kaptoge S, Stoma S, et al. Polygenic basis and biomedical consequences of telomere length variation. Nat Genet. 2021;53:1425–33. - PMC - PubMed
1. Hosnijeh FS, Matullo G, Russo A, Guarrera S, Modica F, Nieters A, et al. Prediagnostic telomere length and risk of B-cell lymphoma-results from the EPIC cohort study. Int J Cancer. 2014;135:2910–7. - PubMed
1. Campa D, Martino A, Varkonyi J, Lesueur F, Jamroziak K, Landi S, et al. Risk of multiple myeloma is associated with polymorphisms within telomerase genes and telomere length. Int J Cancer. 2015;136:E351–8. - PubMed

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Genetically determined telomere length in monoclonal gammopathy of undetermined significance, multiple myeloma risk and outcome

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Genetically determined telomere length in monoclonal gammopathy of undetermined significance, multiple myeloma risk and outcome

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