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Review
. 2025 Feb;16(2):183-197.
doi: 10.1080/20415990.2024.2421155. Epub 2024 Nov 12.

Microencapsulation techniques for developing cannabidiol formulations: a review

Affiliations
Review

Microencapsulation techniques for developing cannabidiol formulations: a review

Ariel Gustavo Garro et al. Ther Deliv. 2025 Feb.

Abstract

Cannabidiol (CBD), extracted from Cannabis sativa L., holds therapeutic promise without inducing psychoactive effects seen with Δ9-tetrahydrocannabinol. Its interaction with the endocannabinoid system plays a pivotal role in regulating mood, pain perception and immune function. Nevertheless, CBD encounters hurdles in clinical application due to its poor bioavailability and water solubility. To overcome these limitations, researchers are exploring microencapsulation techniques, which involve encapsulating CBD within protective matrices. This comprehensive review offers insights into various microencapsulation methods for CBD, scrutinizing their advantages, limitations and implications for formulation optimization. By elucidating the potential of microencapsulation, this review underscores its promise in refining CBD therapy and addressing challenges associated with administration.

Keywords: cannabidiol; cannabis; microencapsulation; natural products; pharmaceutical technology.

Plain language summary

[Box: see text].

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Conflict of interest statement

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

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