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. 2024;15(12):921-937.
doi: 10.1080/20415990.2024.2418800. Epub 2024 Nov 12.

Sodium alginate/carboxymethylcellulose gel formulations containing Capparis sepieria plant extract for wound healing

Sindi P Ndlovu  1 , Shirley C M Motaung  2 , Samson A Adeyemi  3 , Philemon Ubanako  3 , Lindokuhle M Ngema  3 , Thierry Youmbi Fonkui  4 , Derek Tantoh Ndinteh  5 , Pradeep Kumar  3 , Yahya E Choonara  3 , Blessing A Aderibigbe  1
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Sodium alginate/carboxymethylcellulose gel formulations containing Capparis sepieria plant extract for wound healing

Sindi P Ndlovu et al. Ther Deliv. 2024.

Abstract

Aim: Using appropriate wound dressings is crucial when treating burn wounds to promote accelerated healing.Materials & methods: Sodium alginate (SA)-based gels containing Carboxymethyl cellulose (CMC) and Pluronic F127 were prepared. The formulations. SA/CMC/Carbopol and SA/CMC/PluronicF127 were loaded with aqueous root extract of Capparis sepiaria. The formulations were characterized using appropriate techniques.Results: The gels' viscosity was in the range of 676.33 ± 121.76 to 20.00 ± 9.78 cP and in vitro whole blood kinetics showed their capability to induce a faster clotting rate. They also supported high cell viability of 80% with cellular migration and proliferation. Their antibacterial activity was significant against most bacteria strains used in the study.Conclusion: The gels' distinct features reveal their potential application as wound dressings for burn wounds.

Keywords: Capparis Sepiaria; burn wounds; sodium alginate; topical gels; wound dressings; wound healing.

Plain language summary

Burn wounds are difficult to treat when invaded by microbes. Capparis sepiaria plant extract was loaded into gels. The gel formulations were non-toxic, with good antibacterial effects. These features are useful for the treatment of burn wounds.

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Conflict of interest statement

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

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