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Case Reports
. 2024 Oct 11;16(10):e71279.
doi: 10.7759/cureus.71279. eCollection 2024 Oct.

Alveolar Paratesticular Rhabdomyosarcoma in an Adult Patient With PAX3-FOXO1 Fusion and Unfavorable Evolution

Eduardo O Paese  1 , Rubens Rodriguez  2 , Alan A Azambuja  3
Affiliations
Case Reports

Alveolar Paratesticular Rhabdomyosarcoma in an Adult Patient With PAX3-FOXO1 Fusion and Unfavorable Evolution

Eduardo O Paese et al. Cureus. .

Abstract

Rhabdomyosarcomas, malignant mesenchymal tumors of skeletal striated muscle tissue cells, are usually rare in adults. However, when they occur in this population, the prognosis is usually poor, especially if the condition is associated with molecular factors such as the PAX3-FOXO1 fusion. Here, We report a case of paratesticular alveolar rhabdomyosarcoma in an adult patient who initially complained of increased scrotal volume for two years and presented with a PAX3-FOXO1 fusion. This emphasizes the dire prognosis of the disease, reinforcing the need for thorough and directed diagnostic efforts.

Keywords: paratesticular sarcoma; pax3-foxo1; testis cancer; urooncology; uropathology.

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Conflict of interest statement

Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. Pathological examination.
Diffuse infiltration of oval, uneven cells, eosinophilic cytoplasm, and hyperchromatic, slightly eccentric nuclei.
Figure 2
Figure 2. Immunohistochemical examination.
Testicular slide demonstrating positivity for myogenin.
Figure 3
Figure 3. Immunohistochemical examination.
Testicular slide demonstrating positivity for desmin.
See this image and copyright information in PMC

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