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Review
. 2024 Nov 7:17:961-976.
doi: 10.2147/OTT.S468787. eCollection 2024.

Management and Future Therapeutic Perspectives of Classic Kaposi's Sarcoma: An Evidence-Based Review

Nerina Denaro #  1 , Alice Indini #  2 , Lucia Brambilla  3 , Angelo Valerio Marzano  3   4 , Ornella Garrone #  1 , Athanasia Tourlaki #  3
Affiliations
Review

Management and Future Therapeutic Perspectives of Classic Kaposi's Sarcoma: An Evidence-Based Review

Nerina Denaro et al. Onco Targets Ther. .

Abstract

Background: Kaposi sarcoma (KS) is a cutaneous neoplasm of endothelial origin. The causative agent is the human herpes virus-8 (HHV-8) which, combined with an immune system impairment, causes cell proliferation. To date, high-quality evidence and treatment recommendations for the management of KS are confined to the acquired immune deficiency syndrome (AIDS)-related KS, while the clinical approach to the treatment of classic KS (CKS) is based on small retrospective case series and the experience of clinicians in selected referral centers.

Materials and methods: A search of the English literature was conducted through PubMed/MEDLINE databases for studies regarding CKS diagnosis, staging, and treatment, published between January 1990 and September 2023.

Results: Overall, 122 out of 565 articles were selected. Based on the results of this literature review, we proposed indications regarding the recommended flow chart for diagnosis, staging, and follow-up of patients with CKS. We assess available evidences regarding topic, locoregional, and systemic treatments of CKS. We also provide a focus on novel treatment strategies and therapeutic approaches currently under evaluation in clinical trials.

Conclusion: CKS is a rare disease and its management requires a multidisciplinary assessment. Treatment in referral centers and enrolment in clinical trials might impact on outcomes.

Keywords: HHV-8; anti-CTLA-4; anti-PD-1; chemotherapy; classic Kaposi’s sarcoma; guidelines; immunotherapy.

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Conflict of interest statement

Nerina Denaro and Alice Indini are co-first authors for this study. The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Papers screened in the literature review.
See this image and copyright information in PMC

References

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