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. 2025 May 1;109(5):e253-e261.
doi: 10.1097/TP.0000000000005227. Epub 2024 Nov 6.

Association of COVID-19 With Risk of Posttransplant Diabetes Mellitus

Amanda J Vinson  1 , A Jerrod Anzalone  2 , Makayla Schissel  2 , Ran Dai  2 , Amy L Olex  3 , Roslyn B Mannon  4 ; on behalf of the National COVID Cohort Collaborative
Collaborators, Affiliations

Association of COVID-19 With Risk of Posttransplant Diabetes Mellitus

Amanda J Vinson et al. Transplantation. .

Abstract

Background: Posttransplant diabetes mellitus (PTDM) is an important complication for solid organ transplant recipients (SOTRs). COVID-19 has been associated with an increased risk of incident diabetes in the general population. However, the association between COVID-19 and new-onset PTDM has not been explored.

Methods: Using the National COVID Cohort Collaborative Enclave, we conducted a cohort study of adults without diabetes receiving a solid organ transplant (heart, lung, kidney, or liver) in the United States between April 1, 2020, and March 31, 2023, with and without a first diagnosis of COVID-19 (COVID + versus COVID - ) within 180 d of SOT. We propensity score matched a single COVID + SOTR with a COVID - SOTR who was diabetes free at the same point posttransplant. Within this matched cohort, we used multivariable Cox proportional hazards models to examine the adjusted risk of PTDM associated with COVID + .

Results: Among 1342 COVID + SOTRs matched to 1342 COVID - SOTRs, the crude rate of newly diagnosed PTDM in the 2 y post-COVID was 17% in those with versus 13% in those without COVID-19 ( P = 0.007). COVID-19 was significantly associated with new PTDM (adjusted hazard ratio, 1.37; 95% confidence interval, 1.12-1.68 at 2 y).

Conclusions: Similar to other viral infections, COVID-19 is associated with an increased risk of PTDM in SOTRs.

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Conflict of interest statement

The authors declare no conflicts of interest.

References

    1. Jenssen T, Hartmann A. Emerging treatments for post-transplantation diabetes mellitus. Nat Rev Nephrol. 2015;11:465–477.
    1. Hecking M, Werzowa J, Haidinger M, et al.; European-New-Onset Diabetes After Transplantation Working Group. Novel views on new-onset diabetes after transplantation: development, prevention and treatment. Nephrol Dial Transplant. 2013;28:550–566.
    1. Sharif A, Baboolal K. Complications associated with new-onset diabetes after kidney transplantation. Nat Rev Nephrol. 2011;8:34–42.
    1. Jenssen T, Hartmann A. Post-transplant diabetes mellitus in patients with solid organ transplants. Nat Rev Endocrinol. 2019;15:172–188.
    1. Huang JW, Famure O, Li Y, et al. Hypomagnesemia and the risk of new-onset diabetes mellitus after kidney transplantation. J Am Soc Nephrol. 2016;27:1793–1800.

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