Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986 Feb;111(2):213-6.
doi: 10.1530/acta.0.1110213.

Triiodothyronine increases responsiveness of cultured rat bone cells to parathyroid hormone

C Schmid, T Steiner, E R Froesch

Triiodothyronine increases responsiveness of cultured rat bone cells to parathyroid hormone

C Schmid et al. Acta Endocrinol (Copenh). 1986 Feb.

Abstract

Osteoblast-like cells prepared from calvaria of newborn rats and grown in culture for 1 week show markedly increased ornithine decarboxylase (ODC) activity upon exposure to parathyroid hormone (PTH) for 4 h. Triiodothyronine (T3) increases ODC activity of the cultures in long-term experiments but does not stimulate cell replication. Moreover, PTH responsiveness is enhanced by T3. Thus, T3 acts directly on bone cells, and the clinical observation of bone sensitization to PTH by thyroid hormones is confirmed at the cellular level.

PubMed Disclaimer

Publication types

LinkOut - more resources