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. 2024 Nov 12.
doi: 10.1111/cup.14744. Online ahead of print.

Grading Melanocytic Dysplasia: Updated Histopathologic Criteria

Christopher R Shea  1 , Victor G Prieto  2 , Catherine M Shachaf  3 , Scott R Florell  4
Affiliations

Grading Melanocytic Dysplasia: Updated Histopathologic Criteria

Christopher R Shea et al. J Cutan Pathol. .

Abstract

Dr. Martin C. Mihm, Jr.'s innovative work on the dysplastic nevus achieved a milestone in his chapter in the World Health Organisation Classification of Skin Tumours (WHO-C). WHO-C presents a dichotomous classification (high-grade versus low-grade dysplastic nevi) and a quantitative metric to assess melanocytic nuclear enlargement. The Duke classification is a related approach that provides mostly quantitative histopathologic criteria for dysplastic nevi and gives due weight to architectural features as well as cytology. This paper proposes and illustrates updated criteria for scoring and grading melanocytic dysplasia, incorporating some of the definitions and categories of WHO-C, while refining the quantitative and architectural elements of the Duke grading system to facilitate more detailed and precise assessment of dysplastic nevi.

Keywords: dysplasia; dysplastic; grading; melanocytic; nevus.

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References

    1. A. R. Rhodes, T. J. Harrist, C. L. Day, M. C. Mihm, Jr., T. B. Fitzpatrick, and A. J. Sober, “Dysplastic Melanocytic Nevi in Histologic Association With 234 Primary Cutaneous Melanomas,” Journal of the American Academy of Dermatology 9, no. 4 (1983): 563–574, https://doi.org/10.1016/s0190‐9622(83)70171‐4.
    1. A. K. Tong, G. F. Murphy, and M. C. Mihm, Jr., “Dysplastic Nevus: A Formal Histogenetic Precursor of Malignant Melanoma,” Monographs in Pathology 30 (1988): 10–18.
    1. A. R. Rhodes, J. W. Melski, A. J. Sober, T. J. Harrist, M. C. Mihm, Jr., and T. B. Fitzpatrick, “Increased Intraepidermal Melanocyte Frequency and Size in Dysplastic Melanocytic Nevi and Cutaneous Melanoma. A Comparative Quantitative Study of Dysplastic Melanocytic Nevi, Superficial Spreading Melanoma, Nevocellular Nevi, and Solar Lentigines,” Journal of Investigative Dermatology 80, no. 5 (1983): 452–459, https://doi.org/10.1111/1523‐1747.ep12558384.
    1. R. L. Barnhill, H. Kiryu, A. J. Sober, and M. C. Mihm, Jr., “Frequency of Dysplastic Nevi Among Nevomelanocytic Lesions Submitted for Histopathologic Examination. Time Trends Over a 37‐Year Period,” Archives of Dermatology 126, no. 4 (1990): 463–465.
    1. H. Tsao, M. C. Mihm, Jr., and C. Sheehan, “PTEN Expression in Normal Skin, Acquired Melanocytic Nevi, and Cutaneous Melanoma,” Journal of the American Academy of Dermatology 49, no. 5 (2003): 865–872, https://doi.org/10.1016/s0190‐9622(03)02473‐3.

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