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Randomized Controlled Trial
. 2024 Nov 12;24(1):412.
doi: 10.1186/s12871-024-02795-0.

Ciprofol versus propofol for anesthesia induction in cardiac surgery: a randomized double-blind controlled clinical trial

Le Yu  1 , Xiang Liu  1 , Xiang Zhao  1 , Xiu Shan  1 , Evelyne Bischof  2   3 , Hui-Hong Lu  4
Affiliations
Randomized Controlled Trial

Ciprofol versus propofol for anesthesia induction in cardiac surgery: a randomized double-blind controlled clinical trial

Le Yu et al. BMC Anesthesiol. .

Abstract

Background: Ciprofol, a novel intravenous general anesthetic with a chemical structure similar to propofol, exhibits significantly enhanced potency. It offers a rapid onset, reduced incidence of injection pain, and has comparable effects on heart rate and blood pressure to propofol. However, clinical data on its use for anesthesia induction in cardiac surgery remain limited.

Methods: Seventy-eight patients undergoing coronary artery bypass grafting or valve replacement surgery were randomly assigned to receive either ciprofol (N = 40) or propofol (N = 38) for anesthesia induction. Variables recorded included changes in mean arterial pressure and heart rate during anesthesia, alterations in the oxygenation index and lactic acid concentration before and 10 min after anesthesia induction, and the incidence of adverse events such as bradycardia, hypotension, and injection pain.

Results: The incidence of anesthesia-induced injection pain was significantly lower in the ciprofol group compared to the propofol group (3% vs. 18%, P < 0.05). The incidence of other adverse events was similar between the groups. No significant differences in hemodynamics or oxygenation index were observed during anesthesia induction between ciprofol and propofol.

Conclusions: Ciprofol demonstrated a significantly lower incidence of injection pain compared to propofol, potentially improving patient comfort during anesthesia induction. Additionally, ciprofol showed comparable circulatory stability to propofol during anesthesia induction in cardiac surgery, suggesting it may be a suitable alternative to propofol for this application.

Trial registration: The trial was registered at the ClinicalTrials.gov on 03/10/2024 (NCT06312345).

Keywords: Anesthesia induction; Ciprofol; Coronary artery bypass graft; Heart valve replacement; Propofol.

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Conflict of interest statement

Declarations Ethics approval and consent to participate The trial was authorized by the Ethics Committee of East Hospital(2022/No.171), Tongji University, Shanghai, China, and was registered on ClinicalTrials.gov (NCT06312345). The patients/participants provided their written informed consent to participate in this study. Consent for publication Not applicable. Competing interests The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Participants' flowchart
Fig. 2
Fig. 2
Variations in heart rate and blood pressure during anesthesia induction. Error bars represent the standard error of the mean (SEM). T1: before induction of anesthesia; T2: before tracheal intubation; T3: 1 min after tracheal intubation; T4: 5 min after tracheal intubation. ΔMAP: the difference in mean arterial pressure (MAP) calculated as the pressure at each time point minus the baseline pressure (T1). A negative ΔMAP indicates a drop in pressure, while a positive ΔMAP indicates an increase. ΔHR: the difference between the heart rate at each time point and the baseline heart rate. A Mean arterial pressure (MAP) at different time points during anesthesia induction. B Heart rate at different time points during anesthesia induction. C ΔMAP at different time points during anesthesia induction. D ΔHR at different time points during anesthesia induction
See this image and copyright information in PMC

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