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Meta-Analysis
. 2024 Nov 8;103(45):e40476.
doi: 10.1097/MD.0000000000040476.

Osteosarcopenia in patients with cancer: A systematic review and meta-analysis

Chien-Chieh Wang  1 , Hsuan-Chih Liu  2   3 , Wen-Li Lin  4 , Li-Min Wu  5   6 , How-Ran Guo  7   8 , Soon-Cen Huang  9 , Wen-Tsung Huang  10 , Cheng-Yao Lin  1 , Thi-Hoang-Yen Nguyen  8
Affiliations
Meta-Analysis

Osteosarcopenia in patients with cancer: A systematic review and meta-analysis

Chien-Chieh Wang et al. Medicine (Baltimore). .

Abstract

Background: Osteosarcopenia is frequent, and the relative risk of fracture is higher among patients with sarcopenia. It is a strong predictor of poor outcomes in older adults undergoing cancer treatment, suggesting that osteosarcopenia is important in an aging society. This study aimed to evaluate the overall survival (OS) and disease-free survival (DFS) of patients with cancer with and without osteosarcopenia.

Methods: Five electronic databases-Embase, PubMed, Web of Science, Scopus, and CINAHL-were searched for relevant articles published before February 2024. Studies that met the criteria were used to evaluate the OS and DFS of patients with cancer with and without osteosarcopenia. From the 603 initially identified articles, 8 involving 1608 participants were included in the meta-analysis.

Results: We observed that patients with cancer diagnosed with osteopenia, sarcopenia, or osteosarcopenia had worse DFS than those without these conditions. Specifically, osteopenia (pooled hazard ratio [HR] = 1.70, P = .01) and osteosarcopenia (pooled HR = 2.17, P = .0001) emerged as independent predictors of DFS. However, sarcopenia was significantly associated with DFS. The quality of the included studies was generally good, and no publication bias was detected among them for either OS or DFS.

Conclusion: These meta-analysis results suggest that osteopenia and osteosarcopenia are associated with worse DFS among patients with cancer. The use of different case definitions appeared to be a major source of heterogeneity among studies. Further studies are warranted to confirm our findings, especially those regarding OS and DFS.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
PRISMA flowchart of study selection.
Figure 2.
Figure 2.
The association between osteopenia and disease-free survival in patients with cancer.
Figure 3.
Figure 3.
The association between sarcopenia and disease-free survival in patients with cancer.
Figure 4.
Figure 4.
The association between osteosarcopenia and disease-free survival in patients with cancer.
Figure 5.
Figure 5.
(A) Funnel plot of osteopenia and overall survival; (B) Funnel plot of sarcopenia and overall survival.
Figure 6.
Figure 6.
The association between osteopenia and overall survival in patients with cancer.
Figure 7.
Figure 7.
The association between sarcopenia and overall survival in patients with cancer.
Figure 8.
Figure 8.
The association between osteosarcopenia and overall survival in patients with cancer.
See this image and copyright information in PMC

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