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Review
. 2025 Mar;15(3):345-349.
doi: 10.1002/alr.23484. Epub 2024 Nov 13.

Aging and frailty are associated with inflammatory endotypic shifts in patients with chronic rhinosinusitis

Mason R Krysinski  1 , Christina Dorismond  1 , Yash Trivedi  2 , Rory Lubner  1 , Andrea A Lopez  2 , Kolin Rubel  3 , Rakesh K Chandra  1 , Naweed I Chowdhury  1 , Justin H Turner  1   4
Affiliations
Review

Aging and frailty are associated with inflammatory endotypic shifts in patients with chronic rhinosinusitis

Mason R Krysinski et al. Int Forum Allergy Rhinol. 2025 Mar.

Abstract

Frailty and aging are associated with a shift toward non-type 2 inflammation in chronic rhinosinusitis (CRS). Frailty-related shifts in sinonasal inflammatory mediators may be linked to biological senescence. Understanding the role of aging and frailty in CRS may have important treatment implications.

Keywords: aging; chronic rhinosinusitis; cytokine; endotype; frailty; immunosenescence.

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References

REFERENCES

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