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Multicenter Study
. 2024 Dec:92:106148.
doi: 10.1016/j.msard.2024.106148. Epub 2024 Nov 8.

Utility of icobrain for brain volumetry in multiple sclerosis clinical practice

Ai-Lan Nguyen  1 , Maria Pia Sormani  2 , Dana Horakova  3 , Eva H Havrdova  3 , Michael H Barnett  4 , Nicola De Stefano  5 , Marco Battaglini  5 , Manuela Vaneckova  6 , Elaine Lui  7 , Frank Gaillard  7 , Patricia M Desmond  7 , Hayden Prime  8 , Mineesh Datta  8 , Anneke Van der Walt  9 , Vilija G Jokubaitis  9 , Femke Podevyn  10 , Robert Zivadinov  11 , Bianca Weinstock-Guttman  11 , Marie B D'hooghe  12 , Guy Nagels  13 , Vincent Van Pesch  14 , Guy Laureys  15 , Liesbeth Van Hijfte  15 , Jeannette Lechner-Scott  16 , Francesco Patti  17 , Edgardo Cristiano  18 , Juan I Rojas  18 , Diana M Sima  10 , Wim Van Hecke  10 , Tomas Kalincik  19 , Helmut Butzkueven  9
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Free article
Multicenter Study

Utility of icobrain for brain volumetry in multiple sclerosis clinical practice

Ai-Lan Nguyen et al. Mult Scler Relat Disord. 2024 Dec.
Free article

Abstract

Background: Few studies on multiple sclerosis (MS) have explored the variability of percentage brain volume change (PBVC) measurements obtained from different clinical MRIs. In a retrospective multicentre cohort study, we quantified the variability of annualised PBVC in clinical MRIs.

Methods: Clinical MRIs of relapse-onset MS patients were assessed by icobrain. Volumetric data were analysed on same-scanner and different-scanner MRI pairs if they passed quality control criteria. Alignment similarity between two images had to be comparable to same-scanner scan-rescan images.

Results: Of 6826 MRIs, 85 % had appropriate volumetric sequences and 4446 serial MRI pairs were analysed. 3334 (75 %) MRI pairs from 1207 patients met the inclusions. The PBVC of included MRI pairs showed variance of 0.78 % for same-scanner pairs and 0.80 % for different-scanner pairs. Further selection of included MRI pairs with the best variance resulted in 1885 (42 %) MRI pairs with PBVC variance of 0.34 %. Excluded MRI pairs with poor alignment similarity had variances of 2.97 % for same-scanner pairs and 20.79 % for different-scanner pairs.

Conclusion: Icobrain should be utilised for PBVC determination only on selected MRIs with the best alignment similarity. Applying strict selection criteria for the included MRI pairs and longitudinal imaging on the same scanner remain mandatory to reduce PBVC variability.

Keywords: Brain; Icometrix; Real-world; Variability; Volumetry.

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Conflict of interest statement

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Wim Van Hecke reports a relationship with Icometrix NV that includes: board membership and equity or stocks. Diana M. Sima reports a relationship with Icometrix NV that includes: employment. Guy Nagels reports a relationship with Icometrix NV that includes: consulting or advisory and equity or stocks. Femke Podevyn reports a relationship with Icometrix NV that includes: employment. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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