Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2024 Nov 12;57(11):2483-2486.
doi: 10.1016/j.immuni.2024.10.005.

Mx1-ing it up-Mitochondrial relay for interferon-dependent, unconventional IL-1β release in SLE monocytes

Andrea Dorfleutner  1 , Christian Stehlik  2 , Caroline A Jefferies  3
Affiliations
Comment

Mx1-ing it up-Mitochondrial relay for interferon-dependent, unconventional IL-1β release in SLE monocytes

Andrea Dorfleutner et al. Immunity. .

Abstract

The role of type I interferon (IFN-I) in systemic lupus erythematosus (SLE) is well documented, but the role of interleukin (IL)-1β remains elusive. In this issue of Immunity, Caielli et al. identified an SLE monocyte population coproducing IL-1β and IFN-I and described how mitochondrial nucleic-acid-containing RBCs engage cGAS/STING, RIG-I, MDA5, and NLRP3 for unconventional IL-1β release.

PubMed Disclaimer

Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Type I IFN drives unconventional IL-1β secretion in lupus monocytes.
    Caielli S, Balasubramanian P, Rodriguez-Alcazar J, Balaji U, Robinson L, Wan Z, Baisch J, Smitherman C, Walters L, Sparagana P, Nehar-Belaid D, Marches R, Nassi L, Stewart K, Fuller J, Banchereau JF, Gu J, Wright T, Pascual V. Caielli S, et al. Immunity. 2024 Nov 12;57(11):2497-2513.e12. doi: 10.1016/j.immuni.2024.09.004. Epub 2024 Oct 7. Immunity. 2024. PMID: 39378884

References

    1. Caielli S, Cardenas J, de Jesus AA, Baisch J, Walters L, Blanck JP, Balasubramanian P, Stagnar C, Ohouo M, Hong S, et al. (2021). Erythroid mitochondrial retention triggers myeloid-dependent type I interferon in human SLE. Cell 184, 4464–4479 e4419. 10.1016/j.cell.2021.07.021. - DOI - PMC - PubMed
    1. Cao A, and Kagan JC (2022). Gasdermin Pore Forming Activities that Promote Inflammation from Living and Dead Cells. J Mol Biol 434, 167427. 10.1016/j.jmb.2021.167427. - DOI - PMC - PubMed
    1. Caielli S, Balasubramanian P, Rodriguez-Alcazar J, Balaji U, Robinson L, Wan Z, Baisch J, Smitherman C, Walters L, Sparagana P, et al. (2024). Type I IFN drives unconventional IL-1b secretion in lupus monocytes. Immunity. - PMC - PubMed
    1. Zhong Z, Liang S, Sanchez-Lopez E, He F, Shalapour S, Lin XJ, Wong J, Ding S, Seki E, Schnabl B, et al. (2018). New mitochondrial DNA synthesis enables NLRP3 inflammasome activation. Nature 560, 198–203. 10.1038/s41586-018-0372-z. - DOI - PMC - PubMed
    1. Franchi L, Eigenbrod T, Munoz-Planillo R, Ozkurede U, Kim YG, Arindam C, Gale M Jr., Silverman RH, Colonna M, Akira S, and Nunez G (2014). Cytosolic double-stranded RNA activates the NLRP3 inflammasome via MAVS-induced membrane permeabilization and K+ efflux. J Immunol 193, 4214–4222. 10.4049/jimmunol.1400582. - DOI - PMC - PubMed

Publication types

MeSH terms

LinkOut - more resources