Home at last: Mixed signals guide memory T cells to residency
- PMID: 39536712
- DOI: 10.1016/j.immuni.2024.10.008
Home at last: Mixed signals guide memory T cells to residency
Abstract
Tissue-resident memory T (TRM) cells adapt to diverse environments, providing local long-term protection. In this issue of Immunity, Obers et al. and Raynor et al. demonstrate how diet, commensals, and host factors determine TRM cell development, maintenance, and function across tissues.
Copyright © 2024 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests The authors declare no competing interests.
Comment on
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Retinoic acid and TGF-β orchestrate organ-specific programs of tissue residency.Immunity. 2024 Nov 12;57(11):2615-2633.e10. doi: 10.1016/j.immuni.2024.09.015. Epub 2024 Oct 14. Immunity. 2024. PMID: 39406245
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CRISPR screens unveil nutrient-dependent lysosomal and mitochondrial nodes impacting intestinal tissue-resident memory CD8+ T cell formation.Immunity. 2024 Nov 12;57(11):2597-2614.e13. doi: 10.1016/j.immuni.2024.09.013. Epub 2024 Oct 14. Immunity. 2024. PMID: 39406246 Free PMC article.