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Comment
. 2024 Nov 12;57(11):2491-2493.
doi: 10.1016/j.immuni.2024.10.006.

T cells standing at the gates of brain metastasis

Jan Remsik  1 , Adrienne Boire  2
Affiliations
Comment

T cells standing at the gates of brain metastasis

Jan Remsik et al. Immunity. .

Abstract

Insufficient influx of T cells into the tumor microenvironment, including brain metastasis, dramatically limits efficacy of conventional immunotherapy. In this issue of Immunity, Messmer et al. interrogate spatiotemporal dependencies of melanoma brain metastasis T cell infiltration by intravital microscopy. They find that T cells enter these brain tumors through peritumoral venous vessels and can be stimulated with immunotherapy.

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Conflict of interest statement

Declaration of interests J.R. and A.B. are inventors of provisional patent applications related to leptomeningeal metastasis. A.B. is an inventor of patents related to treatment of brain and leptomeningeal metastases.

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