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Comment
. 2024 Nov 12;57(11):2494-2496.
doi: 10.1016/j.immuni.2024.10.009.

TKI resistance in brain metastasis: A CTLA4 state of mind

Elena Donders  1 , Diether Lambrechts  2
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TKI resistance in brain metastasis: A CTLA4 state of mind

Elena Donders et al. Immunity. .

Abstract

Resistance to tyrosine kinase inhibitors (TKIs) in lung cancer brain metastasis (LCBM) remains a clinical challenge. Recently in Cancer Cell, Fu et al. reveal how TKIs reshape the immune microenvironment of LCBM and propose CTLA4 blockade as a promising strategy to overcome resistance.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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