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. 2024 Dec;45(12):1086-1088.
doi: 10.1016/j.tips.2024.10.015. Epub 2024 Nov 12.

Poxvirus vaccines: the evolution of an 18th-century vaccine to the 21st century

Yuhong Xiao  1 , Stuart N Isaacs  2
Affiliations

Poxvirus vaccines: the evolution of an 18th-century vaccine to the 21st century

Yuhong Xiao et al. Trends Pharmacol Sci. 2024 Dec.

Abstract

The unprecedented global spread of monkeypox (mpox) has reinvigorated the pursuit of next-generation poxvirus vaccines. Given the success of the mRNA-lipid nanoparticle (LNP) vaccine platform to vaccinate against SARS-CoV-2, candidate poxvirus mRNA vaccines, as recently reported by Zuiani et al. and Mucker et al., demonstrate success in nonhuman primate (NHP) models and provide insights into the basis of the protective immune response.

Keywords: immune profiling; lipid nanoparticle; mRNA; nonhuman primate.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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