Learning the language of DNA

Christina V Theodoris^{1

2

3}

Affiliations

¹ Gladstone Institute of Cardiovascular Disease, San Francisco, CA, USA.
² Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.
³ Department of Pediatrics, Institute for Human Genetics, and Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.

Comment

Christina V Theodoris. Science. 2024.

. 2024 Nov 15;386(6723):729-730.

doi: 10.1126/science.adt3007. Epub 2024 Nov 14.

Christina V Theodoris^{1

2

3}

¹ Gladstone Institute of Cardiovascular Disease, San Francisco, CA, USA.
² Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.
³ Department of Pediatrics, Institute for Human Genetics, and Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.

Abstract

A genomic foundation model broadly enables sequence modeling, prediction, and design.

Sequence modeling and design from molecular to genome scale with Evo.
Nguyen E, Poli M, Durrant MG, Kang B, Katrekar D, Li DB, Bartie LJ, Thomas AW, King SH, Brixi G, Sullivan J, Ng MY, Lewis A, Lou A, Ermon S, Baccus SA, Hernandez-Boussard T, Ré C, Hsu PD, Hie BL. Nguyen E, et al. Science. 2024 Nov 15;386(6723):eado9336. doi: 10.1126/science.ado9336. Epub 2024 Nov 15. Science. 2024. PMID: 39541441 Free PMC article.