Combination therapy of favipiravir and nitazoxanide to treat respiratory viral infections in severe T-cell deficient children: A single centre experience

Tiphaine Arlabosse¹, Alexandra Y Kreins², Philip Ancliff³, Rossa Brugha⁴, Iek Leng Cheng⁵, Robert Chiesa⁶, Bairavi Indrakumar⁷, Winnie Ip⁸, Amy I Jacobs⁹, Giovanna Lucchini¹⁰, Stephen D Marks¹¹, Elizabeth Rivers¹², Helen Spencer¹³, Austen Worth¹⁴, Seilesh Kadambari¹⁵, Judith Breuer¹⁶

Affiliations

¹ Department of Immunology and Gene Therapy, Great Ormond Street Hospital (GOSH) for Children NHS Foundation Trust, London, UK. Electronic address: tiphaine.arlabosse@gosh.nhs.uk.
² Department of Immunology and Gene Therapy, Great Ormond Street Hospital (GOSH) for Children NHS Foundation Trust, London, UK; Infection, Immunity and Inflammation Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK. Electronic address: a.kreins@ucl.ac.uk.
³ Department of Haematology and Oncology, Great Ormond Street Hospital (GOSH) for Children NHS Foundation Trust, London, UK. Electronic address: philip.ancliff@gosh.nhs.uk.
⁴ Department of Respiratory Medicine, Cardiothoracic Transplantation, Great Ormond Street Hospital (GOSH) for Children NHS Foundation Trust, London, UK. Electronic address: rossa.brugha@gosh.nhs.uk.
⁵ Infection, Immunity and Inflammation Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK; Department of Pharmacy, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK. Electronic address: faniek.cheng@gosh.nhs.uk.
⁶ Department of Bone Marrow Transplant, Great Ormond Street Hospital (GOSH) for Children NHS Foundation Trust, London, UK. Electronic address: robert.chiesa@gosh.nhs.uk.
⁷ Department of Infectious Diseases, Great Ormond Street Hospital (GOSH) for Children NHS Foundation Trust, London, UK. Electronic address: bairavi.indrakumar@gosh.nhs.uk.
⁸ Department of Immunology and Gene Therapy, Great Ormond Street Hospital (GOSH) for Children NHS Foundation Trust, London, UK. Electronic address: winnie.ip@gosh.nhs.uk.
⁹ Infection, Immunity and Inflammation Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK. Electronic address: amy.jacobs.12@ucl.ac.uk.
¹⁰ Department of Bone Marrow Transplant, Great Ormond Street Hospital (GOSH) for Children NHS Foundation Trust, London, UK; Bone Marrow Transplant Unit, IRCCS San Gerardo, Monza, Italy. Electronic address: giovanna.lucchini@irccs-sangerardo.it.
¹¹ Department of Paediatric Nephrology, Great Ormond Street Hospital (GOSH) for Children NHS Foundation Trust, London, UK. Electronic address: stephen.marks@gosh.nhs.uk.
¹² Department of Bone Marrow Transplant, Great Ormond Street Hospital (GOSH) for Children NHS Foundation Trust, London, UK. Electronic address: elizabeth.rivers@gosh.nhs.uk.
¹³ Department of Respiratory Medicine, Great Ormond Street Hospital (GOSH) for Children NHS Foundation Trust, London, UK. Electronic address: helen.spencer@gosh.nhs.uk.
¹⁴ Department of Immunology and Gene Therapy, Great Ormond Street Hospital (GOSH) for Children NHS Foundation Trust, London, UK. Electronic address: austen.worth@gosh.nhs.uk.
¹⁵ Department of Infectious Diseases, Great Ormond Street Hospital (GOSH) for Children NHS Foundation Trust, London, UK. Electronic address: seilesh.kadambari@gosh.nhs.uk.
¹⁶ Infection, Immunity and Inflammation Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK; Department of Infectious Diseases, Great Ormond Street Hospital (GOSH) for Children NHS Foundation Trust, London, UK. Electronic address: j.breuer@ucl.ac.uk.

PMID: 39542044
DOI: 10.1016/j.jinf.2024.106350

Free article

Combination therapy of favipiravir and nitazoxanide to treat respiratory viral infections in severe T-cell deficient children: A single centre experience

Tiphaine Arlabosse et al. J Infect. 2024 Dec.

Free article

. 2024 Dec;89(6):106350.

doi: 10.1016/j.jinf.2024.106350. Epub 2024 Nov 12.

Authors

Affiliations

¹ Department of Immunology and Gene Therapy, Great Ormond Street Hospital (GOSH) for Children NHS Foundation Trust, London, UK. Electronic address: tiphaine.arlabosse@gosh.nhs.uk.
² Department of Immunology and Gene Therapy, Great Ormond Street Hospital (GOSH) for Children NHS Foundation Trust, London, UK; Infection, Immunity and Inflammation Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK. Electronic address: a.kreins@ucl.ac.uk.
³ Department of Haematology and Oncology, Great Ormond Street Hospital (GOSH) for Children NHS Foundation Trust, London, UK. Electronic address: philip.ancliff@gosh.nhs.uk.
⁴ Department of Respiratory Medicine, Cardiothoracic Transplantation, Great Ormond Street Hospital (GOSH) for Children NHS Foundation Trust, London, UK. Electronic address: rossa.brugha@gosh.nhs.uk.
⁵ Infection, Immunity and Inflammation Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK; Department of Pharmacy, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK. Electronic address: faniek.cheng@gosh.nhs.uk.
⁶ Department of Bone Marrow Transplant, Great Ormond Street Hospital (GOSH) for Children NHS Foundation Trust, London, UK. Electronic address: robert.chiesa@gosh.nhs.uk.
⁷ Department of Infectious Diseases, Great Ormond Street Hospital (GOSH) for Children NHS Foundation Trust, London, UK. Electronic address: bairavi.indrakumar@gosh.nhs.uk.
⁸ Department of Immunology and Gene Therapy, Great Ormond Street Hospital (GOSH) for Children NHS Foundation Trust, London, UK. Electronic address: winnie.ip@gosh.nhs.uk.
⁹ Infection, Immunity and Inflammation Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK. Electronic address: amy.jacobs.12@ucl.ac.uk.
¹⁰ Department of Bone Marrow Transplant, Great Ormond Street Hospital (GOSH) for Children NHS Foundation Trust, London, UK; Bone Marrow Transplant Unit, IRCCS San Gerardo, Monza, Italy. Electronic address: giovanna.lucchini@irccs-sangerardo.it.
¹¹ Department of Paediatric Nephrology, Great Ormond Street Hospital (GOSH) for Children NHS Foundation Trust, London, UK. Electronic address: stephen.marks@gosh.nhs.uk.
¹² Department of Bone Marrow Transplant, Great Ormond Street Hospital (GOSH) for Children NHS Foundation Trust, London, UK. Electronic address: elizabeth.rivers@gosh.nhs.uk.
¹³ Department of Respiratory Medicine, Great Ormond Street Hospital (GOSH) for Children NHS Foundation Trust, London, UK. Electronic address: helen.spencer@gosh.nhs.uk.
¹⁴ Department of Immunology and Gene Therapy, Great Ormond Street Hospital (GOSH) for Children NHS Foundation Trust, London, UK. Electronic address: austen.worth@gosh.nhs.uk.
¹⁵ Department of Infectious Diseases, Great Ormond Street Hospital (GOSH) for Children NHS Foundation Trust, London, UK. Electronic address: seilesh.kadambari@gosh.nhs.uk.
¹⁶ Infection, Immunity and Inflammation Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK; Department of Infectious Diseases, Great Ormond Street Hospital (GOSH) for Children NHS Foundation Trust, London, UK. Electronic address: j.breuer@ucl.ac.uk.

PMID: 39542044
DOI: 10.1016/j.jinf.2024.106350

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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Combination therapy of favipiravir and nitazoxanide to treat respiratory viral infections in severe T-cell deficient children: A single centre experience

Affiliations

Combination therapy of favipiravir and nitazoxanide to treat respiratory viral infections in severe T-cell deficient children: A single centre experience

Authors

Affiliations

Conflict of interest statement

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LinkOut - more resources

Full Text Sources