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. 2024 Nov 15;67(1):e75.
doi: 10.1192/j.eurpsy.2024.1784.

Let's focus on the insula in addiction: A refined anatomical exploration of insula in severe alcohol and cocaine use disorders

Pauline Billaux  1 , Shailendra Segobin  2 , Angeline Maillard  3   4 , Vanessa Bloch  4   5   6 , Christine Delmaire  4   7 , Nicolas Cabé  8   9 , Alice Laniepce  8   10 , Pierre Maurage  1 , Margaux Poireau  3   4   5 , Emmanuelle Volle  11 , Florence Vorspan  3   4   5 , Anne-Lise Pitel  8   12
Affiliations

Let's focus on the insula in addiction: A refined anatomical exploration of insula in severe alcohol and cocaine use disorders

Pauline Billaux et al. Eur Psychiatry. .

Abstract

Background: Theoretical and empirical contributions have identified insula as key in addiction. However, anatomical modifications of the insula in addictive states, and their variations across substance use disorders (SUDs), remain to be specifically explored. We therefore explored the specificities and commonalities of insula gray matter (GM) alterations in severe alcohol use disorder (sAUD) and severe cocaine use disorder (sCUD).

Methods: We explored insula GM volume through a refined parcellation in 12 subregions (six bilateral): anterior inferior cortex (AIC), anterior short gyrus, middle short gyrus, posterior short gyrus, anterior long gyrus (ALG), and posterior long gyrus (PLG). Using a linear mixed model analysis, we explored the insula volume profiles of 50 patients with sAUD, 61 patients with sCUD, and 36 healthy controls (HCs).

Results: In both sAUD and sCUD, we showed overall insular lower volume with a right-sided lateralization effect, and a major volume deficit in bilateral ALG. Moreover, differences emerged across groups, with higher left AIC and PLG volume deficits in sCUD compared to sAUD and HC.

Conclusions: We offered the first joint exploration of GM insular volumes in two SUD through refined parcellation, thus unveiling the similarities and dissimilarities in volume deficit profiles. Our results bring evidence complementing prior ones suggesting the core role of the right and posterior insula in craving and interoception, two crucial processes in addiction. Left AIC and PLG group differences also show that, while insula is a region of interest in SUD, sCUD and sAUD generate distinct insular profiles, which might parallel clinical differences across SUD.

Keywords: MRI; addiction; brain volume; parcellation.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1.
Figure 1.
Gray matter volume deficits (z-scores) of insula subregions in sAUD and sCUD patients. AIC, anterior inferior cortex; ALG, anterior long gyrus; ASG, anterior short gyrus; MSG, middle short gyrus; PLG, posterior long gyrus; PSG, posterior short gyrus; sAUD, severe alcohol use disorder; sCUD, severe crack/cocaine use disorder. † = significant difference between the clinical groups, within a subregion; • = significant difference between sAUD and healthy controls, within a subregion; * = significant difference between sCUD and healthy controls, within a subregion For healthy controls, mean z-score = 0, standard deviation z-score = 1.
See this image and copyright information in PMC

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