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. 1979 Apr 15;180(1):153-60.
doi: 10.1042/bj1800153.

Hepatocyte differentiation in culture. Appearance of tyrosine aminotransferase

G C Yeoh, F A Bennett, I T Oliver

Hepatocyte differentiation in culture. Appearance of tyrosine aminotransferase

G C Yeoh et al. Biochem J. .

Abstract

Liver of rat foetuses from 14 to 19 days of gestation and cultured hepatocytes derived from foetuses of 14 or 15 days gestation show a limited capacity to transaminate tyrosine. This low tyrosine transamination activity can be ascribed to aspartate aminotransferase. Definitive tyrosine aminotransferase can be demonstrated in 1-day-old cultures of hepatocytes taken from 19-day foetuses, but not from 15-day foetuses. However, after 3 days of culture hepatocytes from 15-day foetuses are able to synthesize tyrosine aminotransferase. Induction studies reveal that dexamethasone is capable of increasing tyrosine aminotransferase activity once it is detectable in culture.

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