Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Oct 31:11:1475117.
doi: 10.3389/fmed.2024.1475117. eCollection 2024.

Elevated hematologic ratios are correlated with acne severity: a national, retrospective cohort study

Vered Wiesel #  1 , Sarah Weissmann #  1   2 , Bracha Cohen  2 , Inbal Golan-Tripto  1   3 , Amir Horev  1   4
Affiliations

Elevated hematologic ratios are correlated with acne severity: a national, retrospective cohort study

Vered Wiesel et al. Front Med (Lausanne). .

Abstract

Background: Prior studies demonstrated conflicting results regarding hematologic ratios in acne patients. We sought to further characterize hematologic ratios in acne patients, according to demographics and acne severity.

Methods: National, retrospective cohort study of 122,822 patients using medical records from 2005 to 2024 of patients insured with the largest public healthcare organization in Israel, Clalit Health Maintenance Organization.

Results: Moderate-severe acne patients had higher neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) than mild acne patients at diagnosis and 12-18 months before diagnosis. A multivariable regression confirmed the significance of the correlation of increased NLR and PLR with acne severity. Adults and females had higher NLR and PLR than children and males, respectively, at diagnosis, and 12-18 months before diagnosis.

Conclusion: Acne severity was significantly associated with elevated NLR and PLR. NLR and PLR may also serve as indicators of upcoming acne severity, as they were elevated 12-18 months before diagnosis. These biomarkers may contribute to the diagnosis, management, and follow-up of patients with acne.

Keywords: ELR; ENR; NLR; PLR; acne; acne vulgaris; hematologic ratios.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Similar articles

See all similar articles

References

    1. Bhate K, Williams HC. Epidemiology of acne vulgaris. Br J Dermatol. (2013) 168:474–85. doi: 10.1111/bjd.12149 - DOI - PubMed
    1. Vos T, Flaxman AD, Naghavi M, Lozano R, Michaud C, Ezzati M, et al. . Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the global burden of disease study 2010. Lancet. (2012) 380:2163–96. doi: 10.1016/S0140-6736(12)61729-2, PMID: - DOI - PMC - PubMed
    1. Dréno B. Recent data on epidemiology of acne. Ann Dermatol Venereol. (2010) 137:3–5. doi: 10.1016/S0151-9638(10)70045-4 - DOI - PubMed
    1. Lynn DD, Umari T, Dunnick CA, Dellavalle RP. The epidemiology of acne vulgaris in late adolescence. Adolesc Health Med Ther. (2016) 7:13–25. doi: 10.2147/AHMT.S55832, PMID: - DOI - PMC - PubMed
    1. Heng AHS, Chew FT. Systematic review of the epidemiology of acne vulgaris. Sci Rep. (2020) 10:5754. doi: 10.1038/s41598-020-62715-3, PMID: - DOI - PMC - PubMed

LinkOut - more resources