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Review
. 2024 Oct 14;16(10):e71462.
doi: 10.7759/cureus.71462. eCollection 2024 Oct.

Translational Research in Oral Lichen Planus: From Laboratory Discoveries to Clinical Applications

Tejaswini Chintha  1 , Priyadharshini B  1 , Aravindhan R  1 , Magesh K T  1 , Swaathi R  1
Affiliations
Review

Translational Research in Oral Lichen Planus: From Laboratory Discoveries to Clinical Applications

Tejaswini Chintha et al. Cureus. .

Abstract

Oral lichen planus (OLP) is a chronic inflammatory condition that affects the oral mucous membrane, causing discomfort and pain for millions of people worldwide. Challenges in managing OLP include its chronic nature, varied clinical manifestations, poor patient compliance, and potential for malignant transformation. Recent breakthroughs in the therapy of OLP have opened up new paths for dental practitioners, yet persistent difficulties require attention. Topical calcineurin inhibitors, photodynamic treatment, and biologics have all demonstrated success in relieving symptoms and delaying disease progression. Furthermore, advances in understanding OLP's immunopathogenesis have revealed new targets for targeted treatments, raising hopes for more tailored therapy methods. However, obstacles remain, particularly in the area of long-term treatment and the danger of malignant transformation, needing close monitoring and interdisciplinary teamwork. This review will attempt to explore all of the therapeutic strategies for treating OLP that have been addressed in the literature.

Keywords: corticosteroids; dental management; future management; oral lichen planus; photodynamic therapy; treatment choices.

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Conflict of interest statement

Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

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