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Review
. 2024 Oct;14(10):2539-2550.
doi: 10.5455/OVJ.2024.v14.i10.4. Epub 2024 Oct 31.

Acute phase proteins patterns as biomarkers in bacterial infection: Recent insights

Amer Al Ali  1 , Wageh Sobhy Darwish  2
Affiliations
Review

Acute phase proteins patterns as biomarkers in bacterial infection: Recent insights

Amer Al Ali et al. Open Vet J. 2024 Oct.

Abstract

Escherichia coli is a bacterium with command and pathogenic variants. It has been implicated in the induction of several inflammatory conditions. Finding a biomarker for infection began many years ago. The challenge of using acute phase proteins (APPs) as biomarkers for infection is a promising target for many researchers in this field. Many APPs have been studied for their roles as biomarkers of E. coli infection. The following review aims to highlight recent trials that have approved the use of adiponectin, amyloid A, ceruloplasmin, C-reactive protein, Haptoglobin, and Pentraxin 3 as biomarkers for E. coli infection and assess the obtained results. In conclusion, despite the existing approaches for the use of APPs as biomarkers in E. coli infection, we recommend more precise studies to enable these markers to be more specific and applicable in clinical fields. APPs could be markers for systemic inflammatory conditions, regardless of the causative agent.

Keywords: Adiponectin; C-reactive protein; Ceruloplasmin; Escherichia coli; Haptoglobin.

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.. Triangle shows that biomarkers can be specific for diagnosis and useful in monitoring, prediction, and prognosis of the disease.
See this image and copyright information in PMC

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References

    1. Abouelasrar Salama S, De Bondt M, De Buck M, Berghmans N, Proost P, Oliveira V.L.S, Amaral F.A, Gouwy M, Van Damme J, Struyf S. Serum amyloid A1 (Saa1) revisited: restricted leukocyte-activating properties of homogeneous Saa1. Front. Immunol. 2020;11:843. - PMC - PubMed
    1. Ahmed H.F, Hegazy Y.M, Ibrahem S.A. Interrelationship of milk acute-phase proteins and casein percentage in cows and buffaloes subclinical mastitis. Vet. Res. Forum. 2021;12:409–414. - PMC - PubMed
    1. Asgari F, Supino D, Parente R, Polentarutti N, Stravalaci M, Porte R, Pasqualini F, Barbagallo M, Perucchini C, Recordati C, Magrini E, Mariancini A, Riva F, Giordano A, Davoudian S, Roger T, Veer C.V, Jaillon S, Mantovani A, Doni A, Garlanda C. The long pentraxin Ptx3 controls klebsiella pneumoniae severe infection. Front. Immunol. 2021;12:666198. - PMC - PubMed
    1. Aydin O, Ulas N, Genc A, Baysal S, Kandemir O, Aktas M.S. Investigation of hemogram, oxidative stress, and some inflammatory marker levels in neonatal calves with Escherichia coli and coronavirus diarrhea. Microb. Pathog. 2022;173:105802. - PubMed
    1. Balayan S, Chauhan N, Chandra R, Kuchhal N.K, Jain U. Recent advances in developing biosensing based platforms for neonatal sepsis. Biosens. Bioelectron. 2020;169:112552. - PubMed

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