Molecular epidemiology of herpangina in the subcenter of Beijing, China: a surveillance study during 2021-2022

Wan-Xue Zhang^#^{1

2

3}, Lin Zou^#⁴, Yan Cui⁵, Yiguo Zhou^{1

3

6}, Shan-Shan Zhang^{1

2

3}, Han Yang^{1

2

3}, Susu Ding⁵, Qin-Yi Ma^{1

2

3}, Lu Xi⁵, Ran-Ran Zheng⁵, Juan Du^{7

8

9}, Jianming Zhang¹⁰, Qing-Bin Lu^{11

12

13

14

15}

Affiliations

¹ Department of Laboratorial Science and Technology and Vaccine Research Center, School of Public Health, Peking University, Beijing, China.
² Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
³ Center for Infectious Diseases and Policy Research and Global Health and Infectious Diseases Group, Department of Laboratorial of Science and Technology, School of Public Health, Peking University, No 38 Xue-Yuan Rd, Haidian District, Beijing, 100191, China.
⁴ Microbial Testing Department, Beijing Tongzhou District Center for Diseases Control and Prevention, Beijing, China.
⁵ Institute for Infectious Diseases and Endemic Diseases Prevention and Control, Beijing Tongzhou Center for Diseases Prevention and Control, No 1 Luhe zhongxue North St, Tongzhou District, Beijing, 101100, China.
⁶ Department of Health Policy and Management, School of Public Health, Peking University, Beijing, China.
⁷ Department of Laboratorial Science and Technology and Vaccine Research Center, School of Public Health, Peking University, Beijing, China. juandu@bjmu.edu.cn.
⁸ Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China. juandu@bjmu.edu.cn.
⁹ Center for Infectious Diseases and Policy Research and Global Health and Infectious Diseases Group, Department of Laboratorial of Science and Technology, School of Public Health, Peking University, No 38 Xue-Yuan Rd, Haidian District, Beijing, 100191, China. juandu@bjmu.edu.cn.
¹⁰ Institute for Infectious Diseases and Endemic Diseases Prevention and Control, Beijing Tongzhou Center for Diseases Prevention and Control, No 1 Luhe zhongxue North St, Tongzhou District, Beijing, 101100, China. zjm871004@163.com.
¹¹ Department of Laboratorial Science and Technology and Vaccine Research Center, School of Public Health, Peking University, Beijing, China. qingbinlu@bjmu.edu.cn.
¹² Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China. qingbinlu@bjmu.edu.cn.
¹³ Center for Infectious Diseases and Policy Research and Global Health and Infectious Diseases Group, Department of Laboratorial of Science and Technology, School of Public Health, Peking University, No 38 Xue-Yuan Rd, Haidian District, Beijing, 100191, China. qingbinlu@bjmu.edu.cn.
¹⁴ Department of Health Policy and Management, School of Public Health, Peking University, Beijing, China. qingbinlu@bjmu.edu.cn.
¹⁵ Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China. qingbinlu@bjmu.edu.cn.

^# Contributed equally.

PMID: 39546035
DOI: 10.1007/s00705-024-06171-8

Molecular epidemiology of herpangina in the subcenter of Beijing, China: a surveillance study during 2021-2022

Wan-Xue Zhang et al. Arch Virol. 2024.

. 2024 Nov 15;169(12):245.

doi: 10.1007/s00705-024-06171-8.

Authors

Affiliations

¹ Department of Laboratorial Science and Technology and Vaccine Research Center, School of Public Health, Peking University, Beijing, China.
² Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
³ Center for Infectious Diseases and Policy Research and Global Health and Infectious Diseases Group, Department of Laboratorial of Science and Technology, School of Public Health, Peking University, No 38 Xue-Yuan Rd, Haidian District, Beijing, 100191, China.
⁴ Microbial Testing Department, Beijing Tongzhou District Center for Diseases Control and Prevention, Beijing, China.
⁵ Institute for Infectious Diseases and Endemic Diseases Prevention and Control, Beijing Tongzhou Center for Diseases Prevention and Control, No 1 Luhe zhongxue North St, Tongzhou District, Beijing, 101100, China.
⁶ Department of Health Policy and Management, School of Public Health, Peking University, Beijing, China.
⁷ Department of Laboratorial Science and Technology and Vaccine Research Center, School of Public Health, Peking University, Beijing, China. juandu@bjmu.edu.cn.
⁸ Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China. juandu@bjmu.edu.cn.
⁹ Center for Infectious Diseases and Policy Research and Global Health and Infectious Diseases Group, Department of Laboratorial of Science and Technology, School of Public Health, Peking University, No 38 Xue-Yuan Rd, Haidian District, Beijing, 100191, China. juandu@bjmu.edu.cn.
¹⁰ Institute for Infectious Diseases and Endemic Diseases Prevention and Control, Beijing Tongzhou Center for Diseases Prevention and Control, No 1 Luhe zhongxue North St, Tongzhou District, Beijing, 101100, China. zjm871004@163.com.
¹¹ Department of Laboratorial Science and Technology and Vaccine Research Center, School of Public Health, Peking University, Beijing, China. qingbinlu@bjmu.edu.cn.
¹² Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China. qingbinlu@bjmu.edu.cn.
¹³ Center for Infectious Diseases and Policy Research and Global Health and Infectious Diseases Group, Department of Laboratorial of Science and Technology, School of Public Health, Peking University, No 38 Xue-Yuan Rd, Haidian District, Beijing, 100191, China. qingbinlu@bjmu.edu.cn.
¹⁴ Department of Health Policy and Management, School of Public Health, Peking University, Beijing, China. qingbinlu@bjmu.edu.cn.
¹⁵ Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China. qingbinlu@bjmu.edu.cn.

^# Contributed equally.

PMID: 39546035
DOI: 10.1007/s00705-024-06171-8

Abstract

In this study, we analyzed the dynamic molecular epidemiology of herpangina based on pharyngeal swabs and demographic data collected from children with herpangina monitored in Tongzhou district in China from January 2021 to December 2022. A total of 1022 herpangina cases were diagnosed. Out of 225 samples collected, 56.4% (127/225) were positive for non-polio enterovirus, with seven genotypes identified: coxsackievirus A4 (CV-A4), CV-A6, CV-A10, CV-A2, CV-A16, CV-B3, and CV-A8. The predominant genotypes associated with herpangina changed during and after the COVID-19 pandemic, with the predominant genotypes being CV-A4 and CV-A6 in 2021 and CV-A10 and CV-A6 in 2022.

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Conflict of interest statement

Declarations Conflict of interest The authors declare there are no competing interests. Ethical approval All of the participants provided informed consent. The Peking University Institutional Review Board Office granted ethical approval to carry out the study within its facilities (IRB00001052-19005).

References

1. Corsino CB, Ali R, Linklater DR (2024) Herpangina. StatPearls Publishing, Treasure Island (FL)
1. Ye Y-Z, Dou Y-L, Hao J-H et al (2021) Efficacy and safety of interferon α-2b spray for herpangina in children: a randomized, controlled trial. Int J Infect Dis 107:62–68 - DOI - PubMed
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1. Yu H, Li X-W, Liu Q-B et al (2020) Diagnosis and treatment of herpangina: Chinese expert consensus. World J Pediatrics: WJP 16:129–134 - DOI - PubMed
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Molecular epidemiology of herpangina in the subcenter of Beijing, China: a surveillance study during 2021-2022

Affiliations

Molecular epidemiology of herpangina in the subcenter of Beijing, China: a surveillance study during 2021-2022

Authors

Affiliations

Abstract

Conflict of interest statement

References

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical