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. 2025 Aug;48(4):2152-2165.
doi: 10.1007/s10753-024-02181-5. Epub 2024 Nov 15.

STC-1 alleviates airway inflammation by regulating epithelial cell apoptosis through the 5-LO pathway

Shijia Wang  1   2 , Zhijian Tu  2 , Chenping Li  2 , Xiao Jin  2 , Zehong Chen  2 , Xiaofei Ye  2 , Shuyao Xu  2 , Jihao Cai  3 , Chang Cai  4   5
Affiliations

STC-1 alleviates airway inflammation by regulating epithelial cell apoptosis through the 5-LO pathway

Shijia Wang et al. Inflammation. 2025 Aug.

Abstract

Airway inflammation plays a key role in the pathogenesis and development of asthma. Stanniocalcin-1 (STC-1) has powerful antioxidant, anti-inflammatory and anti-apoptotic functions but its impact on the airway inflammation in asthma lacks evidence. Here, we investigated the effect and potential mechanism of STC-1 on airway inflammation through asthmatic mice model and lipopolysaccharide (LPS)-treated BEAS-2B cells. The data showed that STC-1 treatment before the challenge exerted protective effect on ovalbumin (OVA)-induced asthmatic mice, i.e., decreased the inflammatory cell infiltration, mucus secretion, cytokine levels, apoptosis levels, and p38 MAPK signaling. Additionally, STC-1 reduced 5-LO expression. Meanwhile, STC-1 decreased p38 MAPK signaling, cytokine production, mucin MUC5AC production, 5-LO expression and nuclear translocation, and LTB4 production in vitro. Ultimately, transforming growth factor β (TGF- β ), as a 5-LO inducer, reversed the anti-inflammatory and anti-apoptotic effects of STC-1 in BEAS-2B cells by up-regulating 5-LO expression. It reveals the potential of STC-1 to act as an additional therapy to mitigate airway inflammation in asthma and inhibit 5-LO expression.

Keywords: Airway inflammation; Apoptosis; Asthma; Stanniocalcin-1.

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Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests. Ethical approval: The animal study protocol was reviewed and approved by the Laboratory Animal Center of the First Affiliated Hospital of Wenzhou Medical University (WYYYIACUCAEC2023038).

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