Developmental Shifts in Amygdala Function

Abstract

Mammals have evolved with strategies to optimize survival and thrive in their native environment. This includes both physical and behavioral adaptations, and extends to their social environment. However, within a social context, the roles of an animal change across development, and their behavior and biology must update to match these changes. The amygdala has a key role in social and emotional processing and expression, and displays developmental changes in early juvenile, adolescent, and adult transitions. Furthermore, the amygdala is highly sensitive to the social environment. This chapter will describe the primary amygdala developmental changes, how this maps onto major changes in social and emotional domains, and propose a framework where developmental stage of intra-amygdala circuits and its regulation by cortical inputs biases the animal toward developmentally appropriate social and emotional behavior. This developmental plasticity also presents an opportunity for retuning the developmental trajectory in the presence of ongoing challenges during maturation, such as constant threat or resource scarcity, so there can be realignment of behavior to match environmental demands.

Keywords: Amygdala; Fear; Maturation; Social.