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Randomized Controlled Trial
. 2024 Nov 15;29(1):10.
doi: 10.1007/s10006-024-01309-z.

A prospective split-mouth clinical study: comparison of the effect of lornoxicam and etodolac on postoperative sequels following lower third molar surgery

Zulfikar Karabiyik  1 , Mohammad Nabi Basiry  2
Affiliations
Randomized Controlled Trial

A prospective split-mouth clinical study: comparison of the effect of lornoxicam and etodolac on postoperative sequels following lower third molar surgery

Zulfikar Karabiyik et al. Oral Maxillofac Surg. .

Abstract

Purpose: This study aims to compare the efficacy of two non-steroidal anti-inflammatory agents (NSAIDs), namely lornoxicam and etodolac for controlling pain, edema and trismus after removal of lower impacted third molars.

Materials and methods: A total of 20 patients comprised of both genders with bilateral impacted lower impacted third molars (in similar positions) was included in the present study. Patients were randomly assigned either to the lornoxicam group (8 mg of lornoxicam) or to the etodolac group (400 mg of etodolac). The drugs prescribed were handed out immediately after tooth extraction. Postoperative pain was assessed using visual analog scale (VAS). Edema was evaluated using reference lines on the face. Trismus was assessed using a caliper at maximum mouth opening (mm).

Results: There was no significant difference in postoperative pain, trismus, and edema between lornoxicam and etodolac group (p > 0.05).

Conclusions: Based on the results obtained in the present study, ıt has been verified that both lornoxicam and etodolac were adequately effective in the management of pain following third molar surgery. Lornoxicam and etodolac had similar impacts on pain, edema and trismus after impacted lower third molar surgical extractions.

Keywords: Edema; Etodolac; Lornoxicam; Pain; Trismus.

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Conflict of interest statement

Declarations Ethical approval All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the Ethics Committee of Kutahya Health Science University Faculty of Medicine (acceptance number 2022-07/03) and also the Turkish Ministry of Health Medical Drugs and Device Institution with the document number 779718 (date 08/06/2022). The study was registered at clinicaltrials.gov (ID: NCT05679453). Written informed consent was obtained from each patient, all of whom were informed about the study protocol. Competing interests The authors declare no competing interests.

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